The San Diego Padres host the Chicago Cubs on April 29, 2026. First pitch from Petco Park is scheduled for 4:10 p.m. EDT. The game will be broadcast on MARQ.
The Cubs are -104 on the moneyline and by -1.5 on the run line. The Padres are -112 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find my MLB picks and Cubs vs Padres prediction below, as well as probable pitchers, weather report, and more.
Cubs vs Padres Prediction
- Cubs vs Padres Pick: Fernando Tatis Jr. Over 1.5 Total Bases
My Cubs vs Padres best bet is on Fernando's total bases prop. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Padres Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +146 | 9 -110o / -110u | -104 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -178 | 9 -110o / -110u | -112 |
- Cubs vs Padres moneyline: Cubs -104, Padres -112
- Cubs vs Padres over/under: 9 (-110o / -110u)
- Cubs vs Padres spread: Cubs -1.5 (+146), Padres +1.5 (-178)
Cubs vs Padres MLB Betting Preview
San Diego Padres Player Prop
Fernando Tatis Jr. has had a rough start to the season, having yet to hit a single home run. But it’s only a matter of time until he finds his rhythm at the plate, and it’s a good time to buy low on San Diego’s slugger.
Jameson Taillon is set to take the mound for Chicago, and he’s also had a tough start to the season, posting a 4.55 ERA and 1.30 WHIP across his first five outings.
Taillon just can’t sustain velocity on his four-seamer anymore, so he’s been allowing more hard contact than ever — he’s already allowed seven homers. He’s also struggling with his command and control. Both are major issues for a guy who relies on precision pitching and ground balls.
In six career at-bats against Taillon, Tatis is 2-for-6 with a home run and a double.
It is only a matter of time until the Padres’ slugger finds form at the plate, and I think Wednesday afternoon presents a prime opportunity for him to do so versus a pitcher he has already gotten the best of in previous encounters.
Pick: Fernando Tatis Jr. Over 1.5 Total Bases
