The Seattle Mariners host the Chicago White Sox on August 6, 2025. First pitch from T-Mobile Park is scheduled for 9:40 p.m. EDT; the game will be broadcast on ROOT Sports NW.
The Mariners will look to extend their winning streak to three games playing as heavy favorites Wednesday. After a shaky start to the season, George Kirby (4.13 ERA, 72 IP) will look to remain in strong form as he faces off against Jonathan Cannon (94 and 1/3 IP) and a soft White Sox lineup.
Find my MLB betting preview and White Sox vs Mariners prediction below, as well as probable pitchers, betting trends, injury reports and more.
My White Sox vs Mariners Prediction
- White Sox vs Mariners pick: Seattle Mariners -1.5 (-120, Play to -125)
My White Sox vs Mariners best bet is the Mariners to cover the run line. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Mariners Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -102 | 7.5 -105o / -115u | +200 |
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -118 | 7.5 -105o / -115u | -250 |
White Sox vs Mariners Projected Starting Pitchers
| RHP Jonathan Cannon (CHW) | Stat | RHP George Kirby (SEA) |
|---|---|---|
| 4-8 | W-L | 6-5 |
| 0.6 | fWAR (FanGraphs) | 1.2 |
| 4.77/5.04 | ERA /xERA | 4.13/3.61 |
| 4.94/4.77 | FIP / xFIP | 3.60/3.41 |
| 1.41 | WHIP | 1.13 |
| 10.3 | K-BB% | 19.0 |
| 38.7 | GB% | 44.9 |
| 97 | Stuff+ | 97 |
| 100 | Location+ | 115 |
Nick Martin’s White Sox vs Mariners Preview
Chicago White Sox Betting Preview: Offensive Uptick Meets Pitching Concerns
The White Sox have mainly played as underdogs this season and have posted a winning percentage of just 36.9% across the 111 games in which they have been favored to lose. That would suggest +171 as a fair price for an average road game, but in Wednesday's matchup pitting an in-form Kirby versus Cannon on the road Chicago certainly appears to be worthy of being a massive underdog.
Cannon holds an xERA of 5.04 and an xFIP of 4.77 this season, and most metrics suggest the 25-year-old righty has regressed compared to last season. His Pitching+ rating has dropped to 98, and he's been hard-hit 44.9% of the time while striking out just 18% of batters.
Cannon has remained comparably shaky of late, as in his last five starts he's pitched to an ERA of 5.20 and allowed an xBA of .304. He's not been successful when pitching on the road either, as he holds an ERA of 4.94 on the road and an xFIP of 4.89.
The White Sox offense has been in much better form of late, as it ranks seventh in wRC+ over the last 30 days. Throughout the entirety of the season Chicago holds the second-worst wRC+ in MLB versus right-handed pitching and the lowest weighted on-base average in baseball versus RHP.
Miguel Vargas suffered an oblique strain on Friday versus the Los Angeles Angels and will remain sidelined in this matchup.
Seattle Mariners Betting Preview: Kirby Looks to Stay Hot at Home
Kirby struggled early on in the campaign after a late start to the season due to a shoulder injury but has been dominant of late and appears likely to yield much better than average results the rest of the way. Across his first six starts of the season Kirby held an ERA of 5.40, but in the following six outings has pitched to an ERA of 2.80 and an xFIP of 3.17.
Kirby holds a Pitching+ rating of 110 in his last six starts and holds a strikeout minus walk rate of 27.1%. He's also allowed a WHIP of just 0.96 in those outings.
Kirby has always fared well at pitcher-friendly T-Mobile Park, and holds an ERA of 3.43 at home this season, an ERA of just 3.06 at home in 2024, and an ERA of 2.70 at home in 2023.
The Mariners rank seventh in wRC+ versus right-handed pitching this season and will likely be even more productive moving forward thanks to the additions of Eugenio Suarez and Josh Naylor at the trade deadline. Suarez has slugged .575 versus righties this season, while Naylor has slugged .451 versus RHP.
White Sox vs Mariners Prediction, Betting Analysis
The Mariners will have an excellent chance of earning an important win in this matchup as they look to continue chasing down the Houston Astros atop the division.
After a shaky start to the season, Kirby has been in excellent form of late, and it's no surprise to see this level of dominance given his success at the MLB level throughout his young career. Cannon posted below-average results last season as a rookie, and most key metrics suggest he's pitched at a lower level so far this season.
Thanks to the additions of Suarez and Naylor, the Mariners now hold a much more well-rounded lineup and should be one of the most productive units in the league the rest of the way.
Kirby should have a good chance of pitching another gem in this matchup but also could receive plenty of run support with Seattle's potent lineup facing off against a weak starter in Cannon. At -115 there looks to be value backing Seattle to win by two or more, and I would back the Mariners to cover the run-line down to -125.
Pick: Mariners -1.5 -120 (Play to -125)
Moneyline
At -250, there appears to be no value in backing the Mariners to win.
Run Line (Spread)
As outlined, backing the Mariners to cover the run-line is my favorite play from this matchup.
Over/Under
A total of 7.5 looks fair for this matchup as T-Mobile Park has played as the second-most difficult ballpark for run creation this season.
White Sox vs Mariners Betting Trends
