The Houston Astros host the Cincinnati Reds on May 10, 2025. First pitch from Daikin Park is scheduled for 7:10 p.m. ET; the game will be broadcast on FDSOH.
Find our MLB betting preview and Reds vs Astros prediction below, as well as probable pitchers, betting trends and more.
Reds vs Astros Prediction
- Reds vs Astros picks: Reds Moneyline (+110); Under 8
Our Reds vs Astros best bets for Saturday are the Cincinnati moneyline and the game total Under 8. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Astros Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -185 | 8 -102o / -118u | +110 |
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 8 -102o / -118u | -130 |
Reds vs Astros Projected Starting Pitchers
| RHP Brady Singer (CIN) | Stat | RHP Lance McCullers (HOU) |
|---|---|---|
| 4-2 | W-L | 0-0 |
| 0.4 | fWAR (FanGraphs) | 0.2 |
| 3.66/3.62 | ERA /xERA | 0.00/6.59 |
| 3.93/4.01 | FIP / xFIP | 4.31/4.31 |
| 1.14 | WHIP | 1.64 |
| 32.1% | K-BB% | 38.9% |
| 37.6% | GB% | 50.0% |
Reds vs Astros Preview
Steady Singer Against the Returning McCullers
Last Sunday, Lance McCullers Jr. returned to MLB action after almost three years of surgeries, setbacks and rehab.
The right-hander, a member of the 2022 Astros team that won the World Series, made his first start against the Chicago White Sox and threw 3 2/3 scoreless innings.
It's way too early to know what to expect from him after all this time, but the one certainty is Houston will be cautious with him.
On the other side, Brady Singer has thrown three quality starts so far, and with similar stats to his 2024 season, offers reassurance against an Astros lineup that has underperformed.
Houston will miss Yordan Alvarez (out with a right hand strain) and needs Jose Altuve and company to start producing to compensate for the slugger's absence.
This bodes well for today's picks recommended by two Bet Labs systems.
Reds vs Astros Prediction, Betting Analysis
The Road Dogs Interleague Bet Labs system recommends the Reds moneyline.
In Major League Baseball, road underdogs playing interleague games have historically been undervalued by oddsmakers.
Since 2016, despite winning only 43.3% of these games, these teams have generated a consistent positive ROI of 4.6%. This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced —likely due to a lack of familiarity between leagues and public overconfidence in home and favorite teams.
In interleague play, road underdogs have shown themselves to be profitable on the moneyline. They have only a 43.3% win percentage, but those teams have turned a 4.6% ROI for bettors since 2016.
The second pick for this game is the Under, which is based on the weather. According to this Bet Labs system, when the wind blows in at 5–35 mph, fly balls lose carry, and home-run rates drop significantly.
This system targets unders in these conditions with totals between 6–11.
It’s a sharp weather-based angle that exploits environmental factors that are often underweighted in line-setting but heavily affect scoring outcomes.
Picks: Reds moneyline; Under 8 (+310, BetMGM)
Moneyline
As mentioned, we'll back the Reds as a road underdog in interleague play.
Run Line (Spread)
We have no interest in the spread for this game.
Over/Under
We'll go with the Under here.
Reds vs Astros Parlay
- Reds ML
- Under
Parlay odds: +310 (BetMGM)
