The Boston Red Sox host the Cleveland Guardians on September 24, 2026. First pitch from Fenway Park is scheduled for 6:45 p.m. EDT. The game will be broadcast on CLEG.
The Red Sox are favored by -126 on the moneyline and by -1.5 on the run line. The Guardians are +108 on the moneyline and +1.5 on the run line. The total is set at 6.5 runs.
Find my MLB picks and Guardians vs Red Sox prediction below, as well as probable pitchers, weather report, and more.
Guardians vs Red Sox Prediction
- Guardians vs Red Sox Pick: F5 Under 3.5 (-108)
My Guardians vs Red Sox best bet is on the under total runs after the first five innings. Make sure to find the best odds by checking our live MLB odds page and be sure to download the Action Network app for more picks and analysis.
Guardians vs Red Sox Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -196 | 6.5 -128o / 104u | +108 |
| Red Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +162 | 6.5 -128o / 104u | -126 |
- Guardians vs Red Sox moneyline: Guardians +108, Red Sox -126
- Guardians vs Red Sox over/under: 6.5 (-128o / +104u)
- Guardians vs Red Sox spread: Red Sox -1.5 (+162), Guardians +1.5 (-196)
Guardians vs Red Sox Probable Pitchers
| Daniel Espino (RHP, CLE) | Stat | Ranger Suarez (LHP, BOS) |
|---|---|---|
| 0-0 | W-L | 8-4 |
| 0.0 | fWAR (FanGraphs) | 3.7 |
| 4.73/3.53 | ERA / xERA | 3.27/3.73 |
| 4.30/2.73 | FIP / xFIP | 3.12/3.71 |
| 25.4% | K-BB% | 15.2% |
| 43.3% | GB% | TKTKTK |
| .333 | BABIP | TKTKTK |
| 108 | Stuff+ | TKTKTK |
| 101 | Location+ | TKTKTK |
Guardians vs Red Sox MLB Betting Preview
It's chilly with winds blowing in at Fenway again.
Ranger Suarez has allowed just 2 earned runs across 3 starts in September. He's been better against righties than lefties this season, so the matchup shouldn't be an issue, even if Cleveland stuffs the lineup with right-handed bats.
Daniel Espino will open ahead of Joey Cantillo. Espino has been a bit shaky lately, but Cantillo has been tremendous in a bulk relief role.
He's fired 10 scoreless innings, allowing just three hits. Boston ranks 27th or worse in OPS, wOBA, and wRC+ against lefties since the start of August.
Pick: F5 Under 3.5 (-108)
