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Angels vs Tigers Prediction, Pick, MLB Odds for Wednesday, May 27

Angels vs Tigers Prediction, Pick, MLB Odds for Wednesday, May 27 article feature image
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Photo Credit: Patrick Gorski-Imagn Images
Pictured: Jose Soriano walks back to the dugout

The Detroit Tigers host the Los Angeles Angels on May 27, 2026. First pitch from Comerica Park is scheduled for 6:40 p.m. EDT. The game will be broadcast on DSN.

The Tigers are favored by -125 on the moneyline and by -1.5 on the run line. The Angels are +105 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Angels vs Tigers prediction below, as well as probable pitchers, weather report, and more.


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Angels vs Tigers Prediction

  • Angels vs Tigers Pick: NRFI

My Angels vs Tigers best bet is that no runs will be scored in the first inning. Make sure to find the best odds by checking our live MLB odds page.


Angels vs Tigers Odds

Angels Logo
May 27, 2026
6:40 p.m. EDT
DSN
Tigers Logo
Angels Odds
SpreadTotalMoneyline
+1.5
+166
7.5
-110o / -110u
+105
Tigers Odds
SpreadTotalMoneyline
-1.5
-200
7.5
-110o / -110u
-125
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Angels vs Tigers moneyline: Angels +105, Tigers -125
  • Angels vs Tigers over/under: 7.5 (-110o / -110u)
  • Angels vs Tigers spread: Tigers -1.5 (+166 ), Angels +1.5 (-200)

Angels vs Tigers Probable Pitchers

Jose SorianoStatCasey Mize
21-34W-L21-34
1.6fWAR (FanGraphs)1.5
2.44 / 3.70ERA / xERA2.47 / 2.71
3.09 / 3.21FIP / xFIP2.53 / 3.76
17.7K-BB%18.7
51.9GB%34.8
.247BABIP.263
102Stuff+88
105Location+105

Angels vs Tigers MLB Betting Preview

The Tigers host the Angels on Wednesday night at Comerica Park in the second of a three-game set in Detroit.

Tigers’ right-hander Casey Mize will take the mound while Jose Soriano will be on the bump for the Angels in what sets up to be a phenomenal pitching matchup with both starters entering this contest in red-hot form.

Across his first 11 starts in 2026, the Angels’ Dominican right-hander has recorded an impressive 2.44 ERA thus far over 66 frames on the mound. Soriano also ranks inside the top-25 in all of baseball with a 1.07 WHIP this season.

Like Soriano, Detroit’s 29-year-old righty has been unbelievably efficient on the mound, having recorded a 2.47 ERA across eight outings this season.

For two starting pitchers in phenomenal form heading into Wednesday night’s contest, I will be looking to back no runs to be scored in the first inning ahead of this American League clash.

Pick: NRFI


Angels vs Tigers Weather


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Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

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