The slate is small, but there's still betting value to be found.
There are only three games on the MLB slate for Monday, September 22, but our MLB systems and betting experts still found bets worth targeting.
Their MLB predictions and prop picks are below, so continue reading for today's MLB best bets.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 9:40 p.m. | |
  | 9:45 p.m. | |
| 9:45 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Bet Labs' Brewers vs Padres Best Bet
By Bet Labs
This system targets evening games in which public interest in the over is muted, the home team's recent scoring has run slightly hot, and subtle environmental signals align with lower-scoring outcomes.
It focuses on games start between 7:00 p.m. and 11:59 PM ET, and in which the market over percentage sits below 50, suggesting minimal public pressure on inflated totals. Meanwhile, the wind direction — whether blowing in, across the field, or neutral — paired with moderate temperatures between 26 and 74, introduces natural resistance to run scoring. The home team is competitively priced on the moneyline and has a wide win rate window, providing no clear power imbalance that might inflate totals. When layered together, these filters isolate a soft edge in a game environment where bettors overlook the under due to recency bias and lack of extreme public conviction.
Overall, this system is 1501-1143-143 (57%) and has generated a 10% ROI. This season, that ROI has increased to 11% as the system has cashed 58% of its picks (63-45-3).
Pick: Under 7 (+100)
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Derek Carty's Cardinals vs Giants Best Bet
By Derek Carty
There may be some value on Michael McGreevy's walks allowed prop. THE BAT X is projecting him to record 1.20 walks allowed, and oddsmakers are implying 1.81. The model believes there is a 67% chance he issues fewer than two walks. If you can get the under at +125 or better, there is great value.
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Pick: Michael McGreevy Under 1.5 Walks Allowed (+125)
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Bet Labs' Cardinals vs Giants Best Bet
By Bet Labs
The "Silent Sharp Unders" system targets regular-season MLB games where both teams are performing well, yet the total has quietly dropped from open to close.
These are games featuring competent, winning teams with recent success, stable weather conditions, and closing totals in a common scoring range. Despite both teams showing strength, the market subtly favors the under — likely due to matchup specifics or strong pitching. By following this soft signal — when the public eye is more focused on win streaks than totals — this system finds value in betting against inflated scoring expectations.
Overall, this system is 1335-1080-92 (55%) and has generated an 8% ROI.
Pick: Under 8 (-115)
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