The Houston Astros host the Seattle Mariners on May 13, 2026. First pitch from Daikin Park is scheduled for 8:10 p.m. EDT. The game will be broadcast on SCHN.
The Mariners are favored by -124 on the moneyline and by -1.5 on the run line. The Astros are +106 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find my MLB picks and Mariners vs Astros prediction below, as well as probable pitchers, weather report, and more.
Mariners vs Astros Prediction
- Mariners vs Astros Pick: Mariners ML (-130 or Better)
My Mariners vs Astros best bet is on Seattle to win. Make sure to find the best odds by checking our live MLB odds page.
Mariners vs Astros Odds
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +126 | 9 -115o / -105u | -124 |
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -152 | 9 -115o / -105u | +106 |
- Mariners vs Astros moneyline: Mariners -124, Astros +106
- Mariners vs Astros over/under: 9 (-115o / -105u)
- Mariners vs Astros spread: Mariners -1.5 (+126), Astros +1.5 (-152)
Mariners vs Astros Probable Pitchers
| Bryce Miller (RHP, SEA) | Stat | Lance McCullers Jr. |
|---|---|---|
| Season Debut | W-L | 2-3 |
| — | fWAR (FanGraphs) | 0.2 |
| — | ERA / xERA | 7.41 / 4.50 |
| — | FIP / xFIP | 4.80 / 4.16 |
| — | K-BB% | 11.5% |
| — | GB% | 42.7% |
| — | BABIP | .310 |
| — | Stuff+ | 97 |
| — | Location+ | 96 |
Mariners vs Astros MLB Betting Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams:
This system backs teams in regular-season division games after a dominant win over a divisional opponent, leveraging momentum and familiarity in rivalry matchups.
By focusing on teams with win percentages between 16% and 75%, it avoids both extreme outliers and market darlings.
It targets games where teams are priced between -135 and +290, and have just completed a win by six-plus runs — indicating a strong recent performance.
Layering in a moderate home/away streak, and the context of back-to-back division matchups, this strategy aims to exploit situations where public reaction hasn’t fully adjusted to recent blowout results.
Mariners vs Astros Pick, Betting Analysis
We could be scared about backing Bryce Miller in his 2026 debut. Or, it could be a great spot to back a rock-solid starting pitcher at a cheap price.
He was fine in his six Minor League starts (1.98 ERA, 26% strikeout rate), although his control still isn't all the way back (13% walk rate).
Still, I think Miller and the Seattle bullpen provide a massive pitching advantage over whatever Houston throws out there — the Astros' pitching situation is a mess.
Pick: Mariners ML (-130 or Better)
