The Baltimore Orioles host the Toronto Blue Jays on September 22, 2026. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. ET. The game will be broadcast on SNET.
The Orioles are favored by -123 on the moneyline and by -1.5 on the run line. The Blue Jays are +102 on the moneyline and +1.5 on the run line. The total is set at 7 runs.
Find my MLB picks and Blue Jays vs Orioles prediction below, as well as probable pitchers, weather report, and more.
Blue Jays vs Orioles Prediction
- Blue Jays vs Orioles Pick: Samuel Basallo Home Run (+800)
My Blue Jays vs Orioles best bet is Samuel Basallo to hit a homer. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.
Blue Jays vs Orioles Odds
| Blue Jays Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -217 | 7 -120o / 100u | +102 |
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +177 | 7 -120o / 100u | -123 |
- Blue Jays vs Orioles moneyline: Blue Jays +102, Orioles -123
- Blue Jays vs Orioles over/under: 7 (-120o / +100u)
- Blue Jays vs Orioles spread: Blue Jays +1.5 (-217), Orioles -1.5 (+177)
Blue Jays vs Orioles Probable Pitchers
| Max Scherzer (RHP, TOR) | Stat | Chris Bassitt (RHP, BAL) |
|---|---|---|
| 3-8 | W-L | 8-5 |
| 0.0 | fWAR (FanGraphs) | 0.9 |
| 6.07 / 4.33 | ERA / xERA | 4.64 / 4.94 |
| 5.48 / 5.47 | FIP / xFIP | 4.38 / 4.62 |
| 7.3 | K-BB% | 8.0 |
| 31.9 | GB% | 45.7 |
| .252 | BABIP | .332 |
| 94 | Stuff+ | 97 |
| 105 | Location+ | 101 |
Blue Jays vs Orioles MLB Betting Preview, Prediction
Editor's Note: This written pick is a transcription from today's episode of the Payoff Pitch Podcast.
By Derek Carty
I like Orioles catcher Samuel Basallo to hit a home run tonight; he's got great odds, with +800 at DraftKings, and I like this pick down to +580.
Max Scherzer is a shell of the pitcher he used to be. Basallo will have the platoon advantage against him with an extreme hitter's umpire and a good power park.
Even when the Blue Jays starter was good, he had issues against lefty power hitters, and now that he isn't performing well, this is an even better angle to attack him with.
So, I like the way this one sets up.
Pick: Samuel Basallo Home Run (+800, DraftKings)
