The New York Yankees host the Toronto Blue Jays on May 21, 2026. First pitch from Yankee Stadium is scheduled for 7:05 p.m. ET. The game will be broadcast on MLB Network.
The Yankees are favored by -150 on the moneyline and by -1.5 on the run line. The Blue Jays are +125 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Blue Jays vs Yankees prediction below, as well as probable pitchers, weather report, and more.
Blue Jays vs Yankees Prediction
- Blue Jays vs Yankees Pick: Carlos Rodon Over 16.5 Outs (-110)
My Blue Jays vs Yankees best bet is on Carlos Rodon to record 17 outs or more. Make sure to find the best odds by checking our live MLB odds page.
Blue Jays vs Yankees Odds
| Blue Jays Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -175 | 8 -120o / 100u | +125 |
| Yankees Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +145 | 8 -120o / 100u | -150 |
- Blue Jays vs Yankees moneyline: Blue Jays +125, Yankees -150
- Blue Jays vs Yankees over/under: 8 (-120o / +100u)
- Blue Jays vs Yankees spread: Blue Jays +1.5 (-175), Yankees -1.5 (+145)
Blue Jays vs Yankees Probable Pitchers
| RHP Braydon Fisher (TOR) | Stat | LHP Carlos Rodon (NYY) |
|---|---|---|
| 2-1 | W-L | 0-1 |
| 0.2 | fWAR (FanGraphs) | 0.1 |
| 3.08 / 4.35 | ERA / xERA | 5.63 / 4.16 |
| 3.64 / 3.88 | FIP / xFIP | 3.98 / 4.69 |
| 13.9 | K-BB% | 5.3 |
| 43.1 | GB% | 61.1 |
| .254 | BABIP | .263 |
| 99 | Stuff+ | 113 |
| 106 | Location+ | 74 |
Blue Jays vs Yankees MLB Betting Preview
Toronto Blue Jays Betting Preview
The Blue Jays (22-27) cannot figure it out this season. They are 11 and 1/2 games back from the AL East lead, but only two games back from a wild card slot.
Their offseason was notable after replacing Bo Bichette with Japanese star Kazuma Okamoto and then signing Dylan Cease. However, they are far too snake-bitten from injuries to make judgment calls.
They lost Anthony Santander to another shoulder injury in Spring Training (this time requiring surgery). Then, during the season, they lost Addison Barger and Alejandro Kirk within the first few weeks.
Moreover, franchise cornerstone Vladimir Guerrero Jr. is not pulling his weight. The former MVP candidate is posting a 110 wRC+ with just three home runs through 49 games.
Pitching as a whole is not a problem for the Blue Jays, but they have lost significant depth following injuries to Jose Berrios, Max Scherzer, Shane Bieber, Yimi Garcia, Cody Ponce and Tommy Nance.
Unless a significant trade is made before the deadline, this team is likely stuck in limbo until 2027.
New York Yankees Betting Preview
The Yankees are second in the AL East, yet lead the entire AL in run differential. Their season is already on the right track and will only continue forward.
Today's starter, Carlos Rodon, missed nearly two months of action, while tomorrow's starter, Gerrit Cole, will be making his season debut.
Starting pitching was not a massive concern for the 27-time World Champions, but reinforcements are always nice. The biggest issue in the Bronx is its closing situation. Last season's trade deadline acquisitions are both struggling.
David Bednar has a 5.14 ERA, while Camilo Doval has a 5.40 ERA. Both relievers' peripheral stats are not an issue, but one-inning samples are fickle. It remains to be seen whether they can continue testing fans' patience.
Nevertheless, fireballer Carlos LaGrange waits in the wings of Triple-A and could be called upon shortly to provide a boost.
With the offense loaded, the starting pitching healthier and the bullpen just needing an in-house shakeup, there is a lot to like about the Yankees' rest-of-season outlook.
Blue Jays vs Yankees Pick, Betting Analysis
Carlos Rodon has failed to crack five innings pitched in either of his two MLB starts this season.
However, he built up in each of his three minor league starts, with 16 IP through three games. His final start in Triple-A carried most of this weight, as he pitched 6 and 1/3 innings.
Rodon threw 78 pitches and then 88 in each of his first two MLB starts. He is essentially built up as a full starter, despite his eight innings total thus far.
Furthermore, the Blue Jays are one of the worst offensive teams in baseball lately. They have the fourth-worst wRC+ in the past 30 days and rank 20th on the season against left-handed pitching.
While Rodon has not pitched well against offenses worse versus LHP than Toronto, the Blue Jays are 9-16 on the road with the third-worst offense away from home.
The Blue Jays do not strike out much vs LHP (26th), nor do they walk much (16th). There should be plenty of easy outs to keep Rodon's pitch count low each inning.
Pick: Carlos Rodon Over 16.5 Outs (-110, BetMGM)
