The Milwaukee Brewers host the Chicago White Sox on March 28, 2026. First pitch from American Family Field is scheduled for 7:10 p.m. EDT. The game will be broadcast on BREW.
The Brewers are favored by -192 on the moneyline and by -1.5 on the run line. The White Sox are +160 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find our MLB picks and White Sox vs Brewers prediction below, as well as probable pitchers, weather report, and more.
White Sox vs Brewers Prediction
- White Sox vs Brewers Pick: White Sox ML +160
Our White Sox vs Brewers best bet is on the White Sox to win outright. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Brewers Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -130 | 8 -120o / 100u | +160 |
| Brewers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +110 | 8 -120o / 100u | -190 |
- White Sox vs Brewers spread: Brewers -1.5 (+110 ), White Sox +1.5 (-130)
- White Sox vs Brewers over/under: 8.5 (-110o / -110u)
- White Sox vs Brewers moneyline: White Sox +160, Brewers -192
White Sox vs Brewers Projected Starting Pitchers
| Sean Burke (RHP) | 2025 Stats | Chad Patrick (RHP) |
|---|---|---|
| 4-11 | W-L | 3-8 |
| 0.7 | fWAR (FanGraphs) | 2.6 |
| 4.22/4.93 | ERA /xERA | 3.53/3.88 |
| 4.92/4.70 | FIP / xFIP | 3.53/3.98 |
| 1.44 | WHIP | 1.28 |
| 11.7 | K-BB% | 17.3 |
| 45 | GB% | 31.4 |
| 92 | Stuff+ | 105 |
| 101 | Location+ | 99 |
White Sox vs Brewers Preview
Our Bet Labs "Interleague Road Underdog" MLB system recommends going with the White Sox moneyline as road underdogs in this interleague matchup.
The Brewers blew out the White Sox 14-2 on Thursday in the season opener, but oddsmakers may still be undervaluing Chicago here after that lopsided result. Road underdogs in interleague play have historically been mispriced due to a lack of familiarity between leagues and public bias toward home favorites.
They will face Chad Patrick this evening. Patrick had a solid rookie season in 2025, posting a 3.53 ERA with 127 strikeouts in 119 2/3 innings. He brings swing-and-miss stuff, but the White Sox lineup should be motivated to bounce back after getting dominated.
On the other side, Sean Burke takes the ball for the White Sox. Burke delivered 134 1/3 innings last year with a 4.22 ERA and 133 strikeouts, showing durability and the ability to miss bats at a respectable clip even in a rebuilding season. He gives Chicago a chance to keep this game competitive.
White Sox vs Brewers Picks
In Major League Baseball, road underdogs playing interleague games have historically been undervalued by oddsmakers.
This trend has proven reliable across five consecutive seasons, indicating market inefficiencies in how these specific matchups are priced, likely due to a lack of familiarity between leagues and public overconfidence in home and favorite teams.
In interleague play, road underdogs have been profitable on the money line recently. They have only a 43.3% win percentage, but those teams have turned a 4.6% ROI for bettors since 2016 and have been profitable in five consecutive seasons.
Pick: White Sox ML +160
