Indiana vs. Purdue Odds & Betting Predictions - February 21, 2026

Mackey is going to be on fire for this one. Coming off a humbling loss to Michigan, lost at Assembly Hall to the Hoosiers, this is the spot for a Purdue blowout. Indiana by the way, on the road lost by 20 at Illinois, 14 at Michigan, 21 at Michigan State, 9 at Minnesota. You can beat them up and cover big numbers when they’re on the road. Matt Painter, btw, one of the best coaches in American ATS after a loss. Since he started at Purdue in 2005, he’s covered 56% following a loss, seventh best among Power Conference teams in the past 21 years. Perhaps some three point regression looms for opponents, recent games agaisnst MIchigan and Nebraska those two teams shot 46% from 3PT. Hoosiers made 12 three in their first meeting. A little regression and this could be a runaway.