The Louisville Cardinals take on the Indiana Hoosiers in Indianapolis, IN. Tip-off is set for 2 p.m. ET on CBS.
Louisville is favored by -5.5 points on the spread with a moneyline of -245. The total is set at 157.5 points.
Here are my Louisville vs. Indiana predictions and college basketball picks for December 6, 2025.
Louisville vs Indiana Prediction
My Pick: Louisville -5.5 (Play to -6)
My Louisville vs Indiana best bet is on the Cardinals to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Louisville vs. Indiana Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-5.5 -105 | 157.5 -110o / -110u | -245 |
| Indiana Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+5.5 -115 | 157.5 -110o / -110u | +200 |
- Louisville vs Indiana spread: Louisville -5.5
- Louisville vs Indiana over/under: 157.5 points
- Louisville vs Indiana moneyline: Louisville -245, Indiana +200
Louisville vs Indiana College Basketball Betting Preview
Louisville Basketball
Louisville is off to a 7-1 start in year two under Pat Kelsey, with the lone loss coming Wednesday at Arkansas, 89-80. The Cardinals trailed 47-29 at half but battled back with an impressive 51 points after the break to make things interesting.
Louisville is absolutely electric offensively — fourth in efficiency on KenPom while playing at the 10th-fastest tempo. The Cardinals are averaging 19.8 assists per game, ninth-most nationally.
It’s one of the most exciting brands of basketball in the country, as more than half their field goal attempts come from 3-point land. That 54.3% 3-point rate is the third-highest mark in the country, and Kelsey’s group has connected on 35.3% of those attempts so far this year.
Against Arkansas, that 3-point variance swung the wrong way, as the Cards shot just 8-of-37 (22%) from deep. The trio of Mikel Brown Jr., Ryan Conwell and Isaac McKneely combined to go 5-of-30 from 3.
Outlier games happen, of course, but Louisville’s pace, shooting and dribble penetration make it such a nightmare to guard.
Defensively, Louisville has been rock solid as well, sitting 36th on KenPom. The Cardinals have thrived at the rim — opponents are shooting just 41.9% inside the arc, seventh nationally.
Indiana Basketball
Indiana is also 7-1, and like Louisville, it suffered its first loss of the season on Wednesday, falling 73–64 at Minnesota. Darian DeVries has gotten off to a nice start in his first season at the helm, but that opening Big Ten loss highlighted some weaknesses.
Minnesota, which is 4-4 and outside the top 100 on KenPom in both offense and defense, was clearly the better team Wednesday night. Indiana struggled to create clean looks on offense, which was surprising considering the Hoosiers are averaging the sixth-most assists per game nationally.
Indiana was also outrebounded by 15 against a Gophers team that doesn't start anyone taller than 6-foot-8.
Defensively, the Hoosiers have been excellent to start the year. They are 17th on KenPom and have the fourth-best 2-point percentage defense in the country.
Offensively, they have two big-time shooters in Tucker DeVries and Lamar Wilkerson, both above 40% from deep.
Louisville vs. Indiana Betting Analysis
It's a big weekend for Indiana fans in Indianapolis, with this game at Gainbridge Fieldhouse and the Big Ten Championship for football over at Lucas Oil Stadium. Even though it's technically a neutral site and Louisville isn't far from Indy, I still expect an Indiana-heavy crowd.
DeVries has done a very good job with this group and Indiana is a good team, but I think Louisville is on another level from a talent perspective.
The Hoosiers have struggled to score in three of their last five games (a 73-53 home win over Lindenwood and a 69-61 home win over Incarnate Word are two examples), and I expect them to have trouble keeping pace with Louisville.
Indiana has limited opponent 3-point attempts very well this year, ranking 15th nationally in lowest 3-point attempt rate allowed. I don't think that will translate against a Louisville team that forces a ton of 3s by design.
I simply don't see Indiana keeping pace offensively with a more athletic and more talented Louisville team. I'll lay it with the Cardinals.
My Pick: Louisville -5.5 (Play to -6)
