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The Louisville Cardinals take on the Memphis Tigers in Memphis, TN. Tip-off is set for 1 p.m. ET on ESPN.
Louisville is favored by -8.5 points on the spread with a moneyline of -400. The total is set at 162.5 points.
Here’s my Louisville vs. Memphis prediction and college basketball picks for November 15, 2026.
Louisville vs Memphis Prediction
Pick: Memphis +8.5 (Play to +6.5)
My Louisville vs Memphis best bet is on the Tigers to cover the spread. Be sure to find the best lines by using our live NCAAB odds page and download the Action Network app for the latest picks and analysis.
Louisville vs Memphis Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-8.5 -110 | 162.5 -115o / -105u | -400 |
| Memphis Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+8.5 -110 | 162.5 -115o / -105u | +310 |
- Louisville vs Memphis spread: Louisville -8.5 (-110), Memphis +8.5 (-110)
- Louisville vs Memphis over/under: 162.5 (-115 / -105)
- Louisville vs Memphis moneyline: Louisville -400, Memphis +310
Louisville vs Memphis College Basketball Preview
Louisville Basketball
Louisville has opened the season with back-to-back wins and a nice number 10 next to its name.
Pat Kelsey is in his third season and currently only has one scholarship holdover, Adrian Wooley. He's the Cardinals' leading scorer so far this season, and they also have maybe the best portal class in college basketball.
Their best transfer get has to be Flory Bidunga, the excellent interior presence who came over from Kansas. He was the Big 12 Defensive Player of the Year and provides excellent rim protection and rebounding.
But with a new roster, we have yet to see what this Louisville roster will be. The Cards have two wins, by 14 and 50, but those lopsided victories came against Chattanooga and Morehead State, respectively.
This will be their first test of the season.
Memphis Basketball
Memphis will play its third game against a top-25 opponent this season. The Tigers have split the first two matchups, with a win over Iowa State and a loss to Vanderbilt.
Their star Jayden Reid is expected to play, and he leads a plethora of options for Memphis. The Tigers have four players averaging double digits.
For some reason, Penny Hardaway’s Memphis teams start the season out mostly undervalued. Last season was the only campaign in which he didn't lead the Tigers to at least 20 wins.
But overall, this is a rebuilt roster, thanks to a $9 million revenue-share budget. Hardaway brought in 9 NIL portal transfers, as well as three freshmen.
A lot of people have picked Wichita State to win the American, but I think Memphis has so much upside; the value lies with the Tigers.
Louisville vs Memphis Pick, Betting Analysis
I was really close to pulling the trigger on Memphis moneyline.
I think Memphis plays a brand of basketball with just enough toughness to turn this into a dogfight, which is what Hardaway's team likes.
But I think we have to take the points here.
There's a lot of scoring on Memphis, and as long as it can limit getting into bad rhythm shots, it can hang around all game with a chance to win outright.
Protect yourselves with the points here.
Pick: Memphis +8.5 (Play to +6.5)
