The Northwestern Wildcats take on the DePaul Blue Demons in Chicago, IL. Tip-off is set for 8:30 p.m. ET on truTV.
Northwestern is favored by -5.5 points on the spread with a moneyline of -260. The total is set at 141.5 points.
Here’s my Northwestern vs. DePaul prediction and college basketball picks for November 14, 2025.
Northwestern vs DePaul Prediction
My Pick: DePaul +5.5
My Northwestern vs DePaul best bet is on the Blue Demons to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Northwestern vs. DePaul Odds
| Northwestern Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-5.5 -110 | 141.5 -110o / -110u | -260 |
| DePaul Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+5.5 -110 | 141.5 -110o / -110u | +210 |
- Northwestern vs DePaul spread: Northwestern -5.5
- Northwestern vs DePaul over/under: 141.5 points
- Northwestern vs DePaul moneyline: Northwestern -260, DePaul +210
Northwestern vs DePaul College Basketball Betting Preview
This Bet Labs system targets early-season college basketball home teams catching points within their first five games.
These squads often return solid cores from the previous season, typically winning more than 10 games, yet are undervalued by the market due to early uncertainty or stronger non-conference opponents.
The Blue Demons fit into this category for tonight's game against the Wildcats.
Led by CJ Gunn, its lead top scorer (15.7 points per game), DePaul won its first two home games this season against Chicago State and Stonehill.
Last season, despite finishing with 14 wins and 20 losses overall, the Blue Demons performed strongly on their own floor (11-8 record).
This system accounts for that. Playing at home early provides comfort and familiarity during a period when new lineups and rotations are still stabilizing across the country.
The energy of a home crowd, especially in smaller college arenas, can level the playing field.
Bettors tend to overrate established programs in these spots, creating value on competitive home underdogs that are often better prepared than their price suggests.
My Pick: DePaul +5.5
