Clemson vs. Duke Odds & Betting Predictions - November 21, 2026

Clemson at Duke

12:30 am • ESPN
@

Clemson at Duke Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Clemson
6-3
N/A
N/A
N/A
Duke
7-2
N/A
N/A
N/A
location pinSaturday 12:30 a.m.
November 21, 2026
Brooks Field at Wallace Wade StadiumDurham
thermometer image53°Fahrenheit
rain image0%Rain
wind image4Wind

Prop Odds Comparison

Right Arrow
Right Arrow

Loading props…

Line Movement Tracker

Right Arrow
Right Arrow

Clemson vs. Duke Public Betting Percentages

Away Logo

Clemson

Public

50%

Bets%

50%

Money%

NCAAF Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Duke
7-24-13-14-22-0
Clemson
4-51-43-13-21-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Duke
3-61-42-21-51-1
Clemson
4-52-32-21-43-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Duke
7-2N/AN/A4-22-0
Clemson
6-3N/AN/A4-11-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 7th@NCSTW 41-3-4.5 WU 53.5DUKE -192
Oct 31stBCW 47-2-7 WU 49.5DUKE -280
Oct 23rd@UVAW 19-16+2.5 WU 47.5DUKE +112
Oct 17thUNCL 20-24-3 LU 46.5UNC -156
Oct 10th@GTL 25-28-4.5 LO 45.5GT -210
Team Stats
1664
YDS
2111
179/280
Comps/Atts
173/282
5.94
YPA
7.49
4/8
TDs/INTs
14/4
28/152
Sacks/Yards
4/27
1378
Rush Yards
1715
340
Attempts
328
4.05
YPC
5.23
11
TDs
21

Turnovers

Fumbles Lost
8
Interceptions
4

Efficiency

26/30 86.7%
Redzone
34/39 87.2%
40/134 0%
3rd Down
50/119 0%
10/16 0%
4th Down
11/18 0%

First Downs

173
Total
199
73
Pass
99
80
Rush
74
20
Penalty
26
/
Penalties/Yards
/

Clemson vs. Duke Odds Comparison

Right Arrow

Could not load odds

Clemson at Duke Team Totals

MatchupOverUnder
Clemson
6-3
N/A
N/A
Duke
7-2
N/A
N/A