The UConn Huskies take on the Syracuse Orange in Syracuse, NY. Kickoff is set for 12 p.m. ET on ACC Network Extra.
Syracuse is favored by -7 points on the spread with a moneyline of -285. The total is set at 57.5 points.
Here’s my UConn vs. Syracuse predictions and college football picks for Saturday, September 6, 2025.
UConn vs Syracuse Prediction
- UConn vs. Syracuse Pick: UConn +6.5
My Syracuse vs. UConn best bet is on the Huskies spread. Find the best line available on our live NCAAF odds page.
UConn vs Syracuse Odds
| UConn Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -115 | 57.5 -112o / -108u | +230 |
| Syracuse Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -105 | 57.5 -112o / -108u | -285 |
- UConn vs Syracuse point spread: Syracuse -7
- UConn vs Syracuse over/under: 57.5 points
- UConn vs Syracuse moneyline: UConn +230, Syracuse -285
UConn vs Syracuse Pick, Betting Analysis
UConn is the adopted son of the Group of 5, and we are riding with the Huskies against Syracuse.
Last year’s 9-4 record was not a fluke for the Huskies. They dominated in every victory while also losing by five to Duke, three to Wake Forest, and seven to last year’s Syracuse team, which is much better than this year’s version.
UConn quarterback Joe Fagnano returns for his seventh collegiate season after tossing 20 touchdowns to four interceptions last year. While he continues to juggle the position with Wisconsin transfer Nick Evers, the offense is much more effective under Fagnano, who threw for 228 yards and two scores against the Orange last year.
The top two running backs from last year’s squad return (Cam Edwards and Mel Brown), alongside another key back who has recovered from injury (Victor Rosa).
Running the ball has been a strength under head coach Jim Mora, and it should be again this year. The Huskies rushed for 250 yards and four scores in their opener against Central Connecticut, averaging 7.6 yards per carry.
This same group averaged 7.3 yards per carry in last year’s head-to-head matchup with Syracuse — both Edwards and Brown broke off some explosive runs in that game.
Leading receiver Skyler Bell also had a great showing in the Syracuse matchup, pulling in 10 receptions for 113 yards. He reeled in two touchdowns last week.
UConn lost plenty of defensive production from last season, but it also added portal talent on that side of the ball. The Huskies added front-seven players from Iowa State, Nebraska, Virginia, Washington, and Temple (All-AAC linebacker Tyquan King).
Speaking of turnover, Syracuse lost more production than nearly any Power 4 team, ranking 98th nationally in returning production behind one starting offensive player and three starting defensive players.
The Orange lost 45-26 to Tennessee, with App State transfer Joey Aguilar carving them up for three scores.
Even in a 10-win season last year, Syracuse ranked 90th in Success Rate allowed. The Orange won games with an elite passing attack, but that entire group departed in the offseason.
UConn kept this a one-score game last year, and it should keep it closer against a lesser version of the Orange.
UConn does all the little things right, converting in the red zone, getting off the field on third down, and avoiding penalties.
That’s precisely the type of underdog I want to back on the road.
Pick: UConn +6.5
