The Los Angeles Rams (6-2) and San Francisco 49ers (6-3) face off in Week 10 on Sunday, Nov. 9. Kickoff is set for 4:25 p.m. ET from Levi's Stadium in Santa Clara, Calif. The game will broadcast live on FOX.
The Rams are 4.5-point favorites over the 49ers on the spread (Rams -4.5), with the over/under set at 49.5 points. Los Angeles is a -220 moneyline favorite; San Francisco is +180 to pull off the upset.
Let's get into my Rams vs 49ers prediction for today's crucial NFC West battle.
Rams vs 49ers Prediction
- Rams vs 49ers pick: 49ers +4.5 (-110)
My Rams vs 49ers best bet is on San Francisco to cover the spread. Find the best odds by checking our live NFL odds page.
Rams vs 49ers Odds
| Rams Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4.5 -110 | 49.5 -110o / -110u | -220 |
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4.5 -110 | 49.5 -110o / -110u | +180 |
Rams vs 49ers Week 10 Preview
The Rams are undoubtedly great; they are right there with the Seahawks as the cream of the crop in the NFC at the moment — but for me, this is always going to be a 49ers spot as home underdogs.
This spread was at just +3.5, and it's continuing to move in the Rams' direction. It's as high as Rams -5 at some sportsbooks.
These teams played in early October, when an injury-ravaged 49ers squad — it's only gotten worse for San Francisco on that front since — got a lucky win thanks to a Kyren Williams fumble and big game from Mac Jones.
That makes this a revenge spot for the Rams, but 49ers head coach Kyle Shanahan tends to have Sean McVay's number.
The 49ers defense is still decimated, and there are questions about their quarterback situation as well. It’s probably going to be Jones filling in for Brock Purdy again, but that might not be such a bad thing, and they could get Ricky Pearsall back, too.
The Rams are also standing on somewhat shaky ground — and they aren't typically as good when playing outdoors.
Puka Nacua is seemingly getting knocked out of every game, even if he’s still putting up top-10 numbers. Matthew Stafford is far from scrambling, but he's just slinging touchdown passes.
The Rams' recent strength of schedule also hasn't been that impressive. They beat up on the Saints and Jaguars, and also blew out a Ravens team missing Lamar Jackson.
The 49ers offense won't be any less healthy than it was in Week 5 when Jones went off. I think they can put up points again in this spot.
Rams vs 49ers Prediction, Betting Analysis
The coaching matchup is the great equalizer; this is the type of situation where the game should be inside a field goal.
Since 2019, the Rams and 49ers have faced each other 14 times — the underdog is 13-1 against the spread (ATS). Looking at the Shanahan vs. McVay matchup, Shanahan has a 37% ROI against McVay and a 61% straight up (SU) winning percentage on the moneyline.
When McVay is off a multi-game winning streak, the Rams come back down to earth a little bit. They’re 17-28 ATS (38%).
The Rams' kicking situation is also a wild card. Their normal kicker, Joshua Karty, will be sidelined for Harrison Mevis, who was just signed and has never kicked in the NFL.
Fundamentally, I think the Rams are favored by too many points today. Give me the Niners at anything more than plus a field goal.
Pick: 49ers +4.5 (-110)
Spread
My 49ers vs Rams betting prediction is San Francisco to cover the spread.
Moneyline
I have no play on the moneyline.
Over/Under
I have no play on the game total.
