Our football staff is focused on six of Sunday's biggest games for our NFL predictions in Week 15 on December 14.
First, we'll target Bills vs Patriots and Commanders vs Giants in the early window. Later in the afternoon, we have a pair of picks for Colts vs Seahawks and Lions vs Rams. We also have picks for Ravens vs Bengals, Cardinals vs Texans, and more.
Let's dive into our expert NFL picks and best bets for the Week 15 Sunday slate.
NFL Predictions & Picks — Week 15
| Game | Time (ET) | Pick |
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  | 4:25 p.m. | |
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Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Commanders vs Giants
The Giants play fast, averaging over 70.5 offensive snaps per game.
Both teams have pass-heavy tendencies, with the Giants passing the ball on nearly 60% of snaps, and Washington passing the ball on 61.3% of snaps.
These are two of the worst defenses in professional football, ranking 30th and 31st in defensive EPA allowed, respectively. The only defense statistically worse is the Bengals.
Both of these teams rank at the bottom of Action Network's Luck Rankings as well, indicating that positive regression could be due, likely resulting in a plenty of points in this game.
Pick: Over 46.5 (-110)
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Bills vs Patriots
By Brit Devine
I have the Patriots projected as the clear favorites in this game. However, the books currently have them tagged as underdogs.
The Patriots are coming off of a bye week, they are at home, and they already beat the Bills in Buffalo earlier this season when the Bills defense was playing better and healthier than its current state.
The Patriots held James Cook to just 49 yards rushing on 15 attempts, and he should struggle again as the Pats have one of the best run defenses in the league.
On the flip side, the Patriots' run game should be able to gash the Bills on the ground, as the Bills have allowed the 6th-most rushing yards to RBs this season, the 3rd-highest yards per carry, and the most rushing TDs to RBs.
Drake Maye is having a Josh Allen-esque season, filling up the stat sheet without a true elite target to throw to, along with adding value on the ground.
It's going to take an unbelievable game from Allen in order for the Bills to come away with the victory in this game, and while that is possible, I think his output can be matched by Maye and the Patriots offense rather easily.
With a big defensive advantage, along with added rest and home-field advantage, the books simply have the wrong team favored here in my opinion.
Pick: Patriots Moneyline (+100)
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Cardinals vs Texans
By Dylan Wilkerson
Compared to their professional football counterparts, these two teams play relatively fast.
Both are averaging nearly 70 offensive snaps per game, and both rely heavily on their passing game.
The Cardinals are hovering around a 70% pass rate, while Houston is at 62%.
You may wonder why I am taking an over for a game in which Houston's defense is involved.
Keep in mind, this Houston defense is capable of scoring itself or forcing a turnover that leads to points at any given time.
Fast, pass-heavy play and defensive havoc leads me to believe this game will go over the number.
Pick: Over 42.5 (-110)
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Ravens vs Bengals
By Brit Devine
Another game where I think the books have the wrong team favored.
The Bengals just gave the Bills all they could handle last week, while the Ravens managed to lose at home to the Steelers.
Joe Burrow appears to be back in elite form and should have little trouble shredding the Ravens.
On offense, the Ravens have been struggling since Lamar Jackson returned from injury six weeks ago, as he has had trouble staying off of the injury report at points over the past few weeks.
Jackson clearly is not 100%, and once his mobility is in question, it's much harder for him to put the amount of pressure on a defense as he can when healthy.
Since Jackson's return, the Ravens are averaging just 198.5 yards passing per game, have the 9th-lowest completion percentage, and have the lowest highly-accurate throw rate.
With Jackson struggling, the Ravens offense simply doesn't have the juice we are accustomed to.
Even against a beatable Bengals' defense, I don't think the Ravens have enough on offense to keep pace with a Bengals team that is capable of being the highest-scoring team of the week any time they take the field.
Pick: Bengals Moneyline (+125)
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Colts vs Seahawks
This line is already rising, and I want to grab it before it gets any higher.
Indianapolis just lost Daniel Jones to a season-ending Achilles injury. Riley Leonard relieved Jones, but he's dealing with a knee injury.
The Colts signed Philip Rivers this week, and while it's still unclear who is going to start at QB for Indy this week, that's a pretty concerning development (with all due respect to the 44-year-old Rivers).
This was already going to be a tough spot on the road against one of the toughest defenses in the league. This one could get ugly for the Colts.
Pick: Seahawks -13.5 (-115)
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Lions vs Rams
By Dylan Wilkerson
The Rams have an offensive edge in this matchup, just barely beating the Lions in both rush and dropback EPA.
However, when you compare these two teams on defense, the gap is much wider. The Rams rank 2nd in dropback EPA allowed and 3rd in rush EPA allowed.
The Lions find themselves in the middle of the pack in terms of defense, so the advantage is clear.
The Rams should strengthen their grip on the NFC in Week 15.
Pick: Rams -6 (-110)
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