Seahawks vs. 49ers Odds, Picks, Predictions

San Francisco and Seattle renew their NFC West rivalry this week, with the unbeaten 49ers traveling to Lumen Field to face the defending Super Bowl champion Seahawks. Brock Purdy and company have started the season 4-0, while Seattle enters at 3-1 after its only slip came against Washington. Here's how I'm leaning on the spread, moneyline and total ahead of Sunday's 4:25 p.m. ET kickoff; before we dive in, don't forget to grab your Kalshi promo code, read our Kalshi review, and download the Action Network app for more NFL picks and analysis.

Now let's get into my 49ers vs. Seahawks prediction and my NFL predictions for Week 5.

If you want more Action Network content, be sure to add us as a preferred source on Google.

SPREAD

Seahawks opened as a favorite at home, and the number has settled at Seahawks -3.5. That's a modest line for a team hosting the league's only unbeaten club, but it fits a Seahawks squad that's lost just once all season and gets to play in front of one of the loudest crowds in football. Even so, covering that number is close to a coin flip on Kalshi, which suggests the market sees this as a tight divisional game rather than a Seattle blowout.

MONEYLINE

The gap widens straight up. Seattle's price makes the Seahawks clear favorites, in line with a team expected to win roughly three times out of five. San Francisco carries the league's only unbeaten record into Week 5, but that hasn't stopped the market from siding with the champs at home.

TOTAL

At 46.5 points, the total sits in the middle for a Week 5 matchup between two defenses that have both been opportunistic through four games. Activity has leaned toward the Under, with San Francisco's team total trading closer to even odds than Seattle's, pointing to a game that could turn on field position and turnovers more than a shootout..

My Pick: Seahawks moneyline. 

• 49ers-Seahawks Point Spread: 49ers -105 · Seahawks -115
• 49ers-Seahawks Total: Over/Under 46
• 49ers-Seahawks Moneyline: 49ers +137 · Seahawks -163

NFL 2026 Week 5 Predictions

Week 5 of the 2026 NFL season delivers one of its best divisional matchups, as the only unbeaten team left in the NFC, the San Francisco 49ers, heads north to face the defending Super Bowl champion Seattle Seahawks at Lumen Field. Brock Purdy and Christian McCaffrey have the 49ers rolling at 4-0, while Sam Darnold and a Seahawks defense built around last season's title run are off to a 3-1 start of their own.

Seahawks's home-field edge has mattered all season, and Lumen Field's crowd noise has been part of why the Seahawks have lost just once since their title run began. 49ers's offense, with Purdy distributing to McCaffrey and company, has been efficient, but it hasn't faced a defense and environment quite like this one yet.

This matchup has already drawn close to a million dollars in trading volume on Kalshi, and the moneyline gives Seattle a clear edge while the spread sits much closer to even, which tells me the market expects a Seahawks win more than it expects a Seahawks blowout. Taking Seattle to win outright looks like the steadier angle than backing the Seahawks to cover -3.5 in what should be a competitive NFC West clash.

Pick: Seahawks.

• Seattle is pulling the heavier share of activity on the moneyline, with the market pricing the Seahawks as clear favorites to win outright.
• The spread is drawing a far more even split, with Seattle covering -3.5 trading close to a coin flip.
• Total trading has ticked toward the Under, with San Francisco's team total pulling more interest than Seattle's.

San Francisco 49ers vs. Seattle Seahawks is scheduled for 4:25 PM ET, live from Lumen Field in Seattle, Washington. The game is live on FOX.