The English Premier League is in its defining stages. With the leaders looking to keep the chasing pack behind and margins continuously shrinking, each new Premier League matchday brings a surge of betting opportunities.
We have four games to target on today's EPL schedule, and our staff has come up clutch with picks for all of them. So, continue reading for our Premier League best bets for Saturday, March 21.
English Premier League Best Bets
The club logos in the table below represent each match that our soccer betting staff is targeting from today's games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Match | Time (ET) | Pick |
|---|---|---|
  | 8:30 a.m. | |
  | 11 a.m | |
  | 1:30 p.m. | |
  | 4 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our soccer Odds page, which automatically surfaces the best lines for every game. | ||
Liverpool vs. Brighton & Hove Albion
Liverpool’s title defence hasn’t gone according to plan. However, the Reds have just three defeats in their last 18 Premier League matches and have won five of their last six against Brighton, scoring an average of 2.33 goals per game and conceding just 1.17.
Although Mohamed Salah hasn’t been at his best this season, Liverpool remains a potent goal threat. They have scored the fifth-most goals in the Premier League, and also have the fifth-best xG (expected goals).
Brighton side that hasn’t been free-scoring of late. The Seagulls have played 11 league matches in 2026, winning just four and scoring 11 goals. During that run, they have faced three teams that are currently in the top five, losing two and drawing one.
Pick: Liverpool To Win
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Burnley vs. Fulham
Burnley drew 0-0 at home to Bournemouth last weekend, but they have been more threatening on the road. Parker’s team has scored in 11 of their 15 Premier League away matches, netting an average of 1.13 goals per game. However, they have also failed to keep a clean sheet in a Premier League away match.
Fulham have played six Premier League matches at Craven Cottage in 2026, and this bet has won in five of those. During that run, Marco Silva’s side has failed to keep a clean sheet, conceding an average of 1.33 goals per game. However, they have also averaged 1.5 goals per game, earning them 10 points in those matches.
Burnley have nothing to lose at this stage. Scott Parker’s side needs a miraculous turnaround to avoid relegation, so they might as well show some attacking impetus. Fulham’s recent home matches have also been goal-friendly. As a result, both teams to score looks like a good bet here.
Pick: Both Teams to Score – Yes
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Chelsea vs. Everton
While Everton continues to struggle at home, only recently finding their first win after failing to do so in six home matches, Chelsea is exceptional on the road. This season, only Arsenal returned more points from away matches than the Blues’ 25 in 15 games.
Last time away from home, Chelsea dominated against Aston Villa, a rival for the top-four spot. Liam Rosenior’s team allowed a goal, but overcame this obstacle with a stunning 3.60 xG (expected goals) and four in the net.
Everton stopped their negative streak with a 2-0 win over Burnley last time out. However, statistically, they were not as dominant. A similar performance won’t be enough to beat the Blues, making the visitors a value pick.
Pick: Chelsea To Win
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Brentford vs. Leeds United
Leeds are welcoming Brentford to Elland Road and are firmly back in a fight for their Premier League survival, while the visitors are aiming for the European places.
Both teams scored in 60% of Leeds’ Premier League matches this season, while that was the case in 53% of Brentford’s games.
In eight of Leeds’ last 13 home games, both teams produced goals, and considering these two sides are in the bottom half of the table for allowed goals, it would be surprising to see an inefficient duel here.
Five of the previous six head-to-head meetings ended with both teams scoring, including the reverse fixture at Brentford, which finished 1-1.
Pick: Both Teams to Score – Yes
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