Cubs vs. Pirates Odds & Betting Predictions - September 16, 2025

Cubs at Pirates

10:40 pm • SportsNet PT

Chicago Cubs

31-26

4 - 1

Pittsburgh Pirates

29-28

pitcher		team	era	w-l
P.Skenes			1.97	10-10
C.Horton			2.67	11-4

MatchupOpenSpreadTotalMoneyline
Cubs 31-26	+1.5	+1.5-209	o6.5-117	+111
Pirates 29-28	u7	-1.5+172	u6.5-105	-131

Tuesday 10:40 p.m.

September 16, 2025

PNC ParkPittsburgh

Under 0.5 (1st Inn)-170

0.86u

CHC +110

1.1u

Under 6.5+100

CHC +145 (F5)

1.45u

P.Skenes u6.5 Ks+115

1.15u

@DerekCarty https://myaction.app/F6GEecjhIWb

CHC +120

1.2u

@cowhitchurch https://myaction.app/F6GEecjhIWb

CHC +120

0.6u

C.Horton o4.5 Ks+103

0.5u

P.Skenes u6.5 Ks+115

0.49u

PIT -125

CHC +115

0.58u

Bet to +108

CHC +110

1.1u

Skenes pulled after 64 pitches last start. PIT has been conserving young pitchers recently - CHC much better offense, defense, bullpen and base running.

Cubs vs Pirates: Workload Could Tip the Balance
Collin Whitchurch•
Sep 16, 2025 UTC

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No props found

MLB Public Betting

Pirates are 3-2 in their last 5 games.
Pirates are 3-2 in their last 5 games against the spread
Pirates are 15-12 in their road games against the spread
The totals have gone OVER in 3 of Pirates' last 5 games
The totals have gone OVER in 19 of Pirates' 30 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pirates	30-27	15-15	15-12	17-15	12-12
Cubs	23-34	12-17	11-17	14-22	9-12

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pirates	30-25-2	19-11	11-14-2	20-12	9-13-2
Cubs	32-25	15-14	17-11	18-18	14-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pirates	29-28	15-15	14-13	18-14	10-14
Cubs	31-26	18-11	13-15	21-15	10-11

date	opponent	score	spread	over/under	moneyline
Sep 15th	CHC	L 0-4	+1.5 L	U 8	CHC +102
Sep 14th	@WSH	L 3-4	-1.5 L	U 8.5	WSH -120
Sep 13th	@WSH	W 5-1	-1.5 W	U 9	PIT -115
Sep 12th	@WSH	L 5-6	-1.5 L	O 8.5	WSH -110
Sep 11th	@BAL	L 2-3	+1.5 W	U 8	BAL +105

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RC.Horton, P	79	5	6	1
LD.Pomeranz, P	15	1	2	0
RA.Kittredge, P	11	1	2	0
LC.Thielbar, P	12	1	0	0
RB.Keller, P	12	1	2	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	3-4	2	1	1
2N.Hoerner, 2B	3-5	0	0	0
3I.Happ, LF	0-2	1	0	1
4M.Ballesteros, DH	2-4	1	0	0
5C.Kelly, C	2-5	0	0	0
6P.Crow-Armstrong, CF	1-4	0	0	2
7D.Swanson, SS	2-4	0	0	0
8W.Castro, RF	0-5	0	0	0
9M.Shaw, 3B	1-4	0	0	0

PITCHER	PC	IP	K	ER
RP.Skenes, P	92	3.2	6	3
LE.Sisk, P	21	1	1	1
RJ.Lawrence, P	17	1.1	1	0
RC.Mlodzinski, P	55	3	5	0

HITTERS	H-AB	R	RBI
1J.Triolo, 3B	0-4	0	0
2S.Horwitz, 1B	1-3	1	0
3B.Reynolds, DH	0-4	0	0
4O.Cruz, CF	1-4	0	1
5N.Gonzales, SS	0-4	0	0
6J.Suwinski, LF	0-3	0	0
7N.Yorke, 2B	0-3	0	0
8A.Canario, RF	1-3	0	0
9H.Davis, C	1-3	0	0