Giants vs Cardinals Odds: Moneyline, Over/Under, Props - September 16, 2026

Giants at Cardinals

5:15 pm • NBCS-BA

San Francisco Giants

0-0

6 - 5

St. Louis Cardinals

0-0

pitcher		team	era	w-l
M.Liberatore			5.23	6-14
A.Molina			3.72	3-2

MatchupOpenSpreadTotalMoneyline
Giants 0-0	+1.5	+1.5-152	o8.5-104	+140
Cardinals 0-0	u8.5	-1.5+131	u8.5-118	-163

Wednesday 5:15 p.m.

September 16, 2026

Busch StadiumSt. Louis

SF +140

1.4u

Under 8.5-124

0.62u

(FD - need 8.5) Run environment 6% below average and should stay that way with just a small boost from weather + umpire. Both pitchers have been far better than ERA (Molina barely below 4, Liberatore just below 4.5). Proj. SFG LU avg 69 wRC+ v LHP. Defenses combine to be about neutral. BARTOLO has two bottom third of the league pens, but STL pen estimators 11th best L30 days.

Largest Prop Edge for Giants vs Cardinals
Action Network Staff•
Sep 16, 2026 UTC

See more MLB Coverage

Loading props…

MLB Public Betting

Cardinals are 1-4 in their last 5 games.
Cardinals are 3-2 in their last 5 games against the spread
Cardinals are 45-36 in their road games against the spread
The totals have gone OVER in 2 of Cardinals' last 5 games
The totals have gone OVER in 36 of Cardinals' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	86-76	41-40	45-36	17-34	68-40
Giants	80-82	41-40	39-42	21-27	58-54

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	74-82-6	36-42-3	38-40-3	24-26-1	48-55-5
Giants	75-77-10	36-42-3	39-35-7	27-18-3	47-58-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	77-85	38-43	39-42	25-26	51-57
Giants	65-97	37-44	28-53	24-24	40-72

date	opponent	score	spread	over/under	moneyline
Sep 15th	SF	L 3-10	-1.5 L	O 8.5	SF -180
Sep 14th	SF	W 2-1	-1.5 L	U 8	STL -153
Sep 13th	CWS	W 3-1	+1.5 W	U 8.5	STL -106
Sep 12th	CWS	L 5-6	+1.5 W	O 8.5	CWS -111
Sep 12th	CWS	W 7-3	+1.5 W	O 7.5	STL -110

Hayden Birdsong
SP
Birdsong is out with arm
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RA.Molina, P	82	5.2	6	0
LP.Abner, P	4	0.1	1	0
RC.Seymour, P	29	0.2	0	0
RT.Harris, P	14	1.1	2	0
RD.Smith, P	28	0.2	1	2
LR.Sanmartin, P	1	0.1	0	0
RJ.Kuhnel, P	17	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Cox, CF	3-4	1	0	1
1J.Cox, 2B	3-4	1	0	1
2B.Eldridge, 1B	0-3	0	0	0
2G.McCray, PR	0-0	1	0	0
2G.McCray, RF	0-0	1	0	0
3B.Harris, 3B	1-4	0	0	0
3D.Gilbert, PH	1-1	1	1	2
3D.Gilbert, CF	1-1	1	1	2
4J.Lee, DH	0-4	0	0	0
5S.Whitcomb, 2B	2-5	1	0	0
5S.Whitcomb, 1B	2-5	1	0	0
6T.Hill, LF	1-5	0	0	0
7A.Knizner, C	3-4	1	0	1
8S.Bandura, RF	1-4	0	0	0
8O.Basabe, 3B	0-0	0	0	0
9C.Koss, SS	1-4	1	0	0

PITCHER	PC	IP	K	ER
LM.Liberatore, P	81	6	2	1
RL.Gastelum, P	17	1	2	1
LJ.Bruihl, P	10	0.2	0	0
RG.Graceffo, P	14	1.1	1	0
RR.O'Brien, P	16	1	0	1

HITTERS	H-AB	R	RBI
1J.Wetherholt, 2B	0-3	0	0
1J.Fermin, 2B	0-1	0	1
1J.Fermin, LF	0-1	0	1
2L.Bernal, DH	1-5	0	1
2L.Bernal, C	1-5	0	1
3A.Burleson, 1B	1-5	1	0
4J.Walker, RF	0-3	1	0
5J.Baez, LF	0-4	0	0
5B.Torres, PH	0-0	0	0
5V.Scott, PR	0-0	0	0
6N.Gorman, 3B	0-3	1	0
7T.Saggese, SS	1-4	2	1
7T.Saggese, 2B	1-4	2	1
8N.Church, CF	2-5	0	0
9P.Pages, C	0-2	0	0
9I.Herrera, PH	0-0	0	0
9M.Winn, PR	0-0	0	0
9M.Winn, SS	0-0	0	0