The St. Louis Cardinals host the San Francisco Giants on September 16, 2026. First pitch from Busch Stadium is scheduled for 1:15 p.m. ET. The game will be broadcast on NBCS-BA.
The Cardinals are favored by -164 on the moneyline and by -1.5 on the run line. The Giants are +136 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find our MLB picks and Giants vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Giants vs Cardinals Prediction
- Giants vs Cardinals Pick: Turner Hill Over 0.5 Singles (-102)
Our Giants vs Cardinals best bet is on Turner Hill to hit a single this afternoon. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.
Giants vs Cardinals Odds
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -162 | 8 -110o / -110u | +136 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +134 | 8 -110o / -110u | -164 |
- Giants vs Cardinals moneyline: Giants +136, Cardinals -164
- Giants vs Cardinals over/under: 8 (-110o / -110u)
- Giants vs Cardinals spread: Giants +1.5 (-162), Cardinals -1.5 (+134)
Giants vs Cardinals Probable Pitchers
| Anthony Molina (RHP, SF) | Stat | Matthew Liberatore (LHP, SL) |
|---|---|---|
| 3-1 | W-L | 5-14 |
| 0.3 | fWAR (FanGraphs) | 0.9 |
| 5.24 / 4.36 | ERA / xERA | 5.53 / 5.07 |
| 3.82 / 3.77 | FIP / xFIP | 4.71 / 4.05 |
| 14.9 | K-BB% | 15.0 |
| 38.2 | GB% | 36.3 |
| .299 | BABIP | .337 |
| 102 | Stuff+ | 98 |
| 104 | Location+ | 99 |
Giants vs Cardinals MLB Betting Preview
Action PRO projects Giants LF Turner Hill for 1.07 singles this afternoon against the Cardinals, giving us a nice 15.2% edge when compared to his current prop line of over/under 0.5, which is good enough to mark the over with an A- grade in our system.
Even though this is a lefty-on-lefty matchup against Matthew Liberatore, Hill has no disadvantage, as he's hitting .250 vs. both RHP and LHP.
However, the home/away split is more telling: Hill is averaging .371 on the road, which bodes well for our prop.
He has a single in each of the two previous matchups of this series, and we'll back him today to get a third in a row against St. Louis.
Pick: Turner Hill Over 0.5 Singles (-102, DraftKings)
