Twins vs. Red Sox Odds & Betting Predictions - May 22, 2026

Twins at Red Sox

11:10 pm • NESN
@
Starting Pitchers
pitcherteameraw-l
Payton Tolle logoP.TolleBoston Red Sox logo2.052-2
Connor Prielipp logoC.PrielippMinnesota Twins logo2.881-2

Twins at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
23-27
+1.5
+1.5-180
o7.5+105
+125
Red Sox
22-27
u7.5
-1.5+145
u7.5-119
-152
location pinFriday 11:10 p.m.
May 22, 2026
Fenway ParkBoston
thermometer image60°Fahrenheit
rain image0%Rain
wind image6Wind
Twins vs. Red Sox Expert Picks
Austin Pendergrass
Austin Pendergrass
Last 30d: 35-22-0 (+2.6u)
Under 8.5-154
0.5u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 75-95-10 (+8.9u)
Under 7.5-105
0.5u
@Zerillo ⭐️⭐️ https://myaction.app/mcSZfWMQl3b
Frank Ammirante
Frank Ammirante
Last 30d: 250-266-10 (-8.2u)
P.Tolle o15.5 Outs-115
1.15u
Under 7.5-105
1.05u
Adam Kaufman
Adam Kaufman
Last 30d: 28-37-0 (-13.5u)
BOS -148
1.48u
Sean Zerillo
Sean Zerillo
Last 30d: 172-143-12 (+6.0u)
Under 8-118
0.59u
Bet to 7.5 (-105)

Twins vs. Red Sox Previews & Analysis

  • Adam Trigger's Triple-A Baseball Picks for Friday article feature image

    Adam Trigger's Triple-A Baseball Picks for Friday

    Adam Trigger
    May 22, 2026 UTC
  • Twins vs Red Sox: Zerillo's Over/Under Pick for Friday article feature image

    Twins vs Red Sox: Zerillo's Over/Under Pick for Friday

    Sean Zerillo
    May 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Red Sox Public Betting Percentages

Away Logo

Twins

Public

23%

Bets%

77%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
19-307-1512-1512-196-11
Twins
26-2417-129-127-719-16

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
21-27-15-16-116-1113-17-18-9
Twins
27-19-414-11-413-87-6-119-13-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
22-278-1414-1315-166-11
Twins
23-2715-148-136-817-18

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 20th@KCW 4-3-1.5 LU 7.5BOS +100
May 19th@KCW 7-1-1.5 WO 7.5BOS -138
May 18th@KCW 3-1-1.5 WU 9BOS -113
May 17th@ATLL 1-8+1.5 LO 8.5ATL +122
May 16th@ATLW 3-2-1.5 LU 7.5BOS +100

Red Sox vs. Twins Injury Updates

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Patrick Sandoval
    SP

    Sandoval is out with elbow

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

  • Romy Gonzalez
    1B

    Gonzalez is out with shoulder

    Out

Twins Injuries

  • Pablo Lopez
    SP

    Lopez is out with elbow

    Out

  • David Festa
    SP

    Festa is out with shoulder

    Out

  • Travis Adams
    SP

    Adams is out with triceps

    Out

Twins vs. Red Sox Starting Lineups
Twins Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Connor Prielipp logoLC.Prielipp, P1-22.880.96010.44
HITTERSAVGOBPSLGHR
Byron Buxton logo1B.Buxton, DH.260.320.57615
Brooks Lee logo2B.Lee, 3B.248.299.3885
Austin Martin logo3A.Martin, CF.293.413.3741
Josh Bell logo4J.Bell, 1B.231.295.3645
Ryan Kreidler logo6R.Kreidler, SS.296.406.6673
Kody Clemens logo7K.Clemens, RF.240.333.4214
Luke Keaschall logo8L.Keaschall, 2B.227.311.3021
Red Sox Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Payton Tolle logoLP.Tolle, P2-22.050.7838.80
HITTERSAVGOBPSLGHR
Jarren Duran logo1J.Duran, LF.195.266.3626
Ceddanne Rafaela logo2C.Rafaela, CF.287.353.4394
Wilyer Abreu logo3W.Abreu, RF.292.359.4386
Willson Contreras logo4W.Contreras, 1B.269.369.49710
Andruw Monasterio logo5A.Monasterio, DH.250.294.3881
Nick Sogard logo6N.Sogard, SS.286.375.3570
Marcelo Mayer logo7M.Mayer, 2B.221.290.3132
Carlos Narvaez logo8C.Narvaez, C.221.295.3372
Caleb Durbin logo9C.Durbin, 3B.168.247.2451

Twins vs. Red Sox Odds Comparison

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Twins at Red Sox Team Totals

MatchupOverUnder
Twins
23-27
N/A
N/A
Red Sox
22-27
N/A
N/A