Pirates vs. Reds Odds & Betting Predictions - September 25, 2025

Pirates at Reds

4:40 pm • SportsNet PT

Pittsburgh Pirates

0-0

1 - 2

Cincinnati Reds

0-2

pitcher		team	era	w-l
N.Lodolo			3.33	9-8
B.Ashcraft			2.71	4-4

MatchupOpenSpreadTotalMoneyline
Pirates 0-0	+1.5	+1.5-154	o7.5-111	+144
Reds 0-2	u8.5	-1.5+127	u7.5-108	-172

Thursday 4:40 p.m.

September 25, 2025

Great American Ball ParkCincinnati

Under 4 (F5)+100

CIN -161 (F5)

0.62u

CIN -169

0.59u

Under 8.5-115

0.5u

Must-win game for the Reds. I don’t love that Lodolo is projected to face an entire lineup of righties but the Reds probably treat this game as an all-hands-on-deck and won’t leave him out there if he’s struggling or in trouble. On the other side the Pirates are sending out Braxton Ashcraft, who I like long-term. Owns a 2.62 ERA backed by a 3.45 xERA, so I don’t think it’s fluky. His 8.5% BB% and 0.41 HR/9 ratio have been very good. Let’s back the pitching in this game and take the Under 👇

Thursday's Random MLB Sharp Action Alert!
PJ Walsh•
Sep 25, 2025 UTC
Pirates vs Reds: Spread Pick for This Afternoon
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Sep 25, 2025 UTC

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No props found

MLB Public Betting

Reds are 3-2 in their last 5 games.
Reds are 2-3 in their last 5 games against the spread
Reds are 42-39 in their road games against the spread
The totals have gone OVER in 1 of Reds' last 5 games
The totals have gone OVER in 26 of Reds' 79 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Reds	82-78	40-39	42-39	29-43	53-34
Pirates	90-72	48-33	42-39	19-26	69-45

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Reds	58-91-11	26-45-8	32-46-3	20-47-5	37-44-6
Pirates	61-92-9	33-43-5	28-49-4	17-26-2	42-65-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Reds	83-79	44-35	38-43	39-33	43-44
Pirates	71-91	44-37	27-54	22-23	48-66

date	opponent	score	spread	over/under	moneyline
Sep 24th	PIT	L 3-4	-	U 7	PIT -102
Sep 23rd	PIT	L 2-4	-1.5 L	U 8	PIT -101
Sep 21st	CHC	W 1-0	-1.5 L	U 9	CIN -126
Sep 20th	CHC	W 6-3	+1.5 W	U 9	CIN -114
Sep 19th	CHC	W 7-4	+1.5 W	O 8	CIN -110

Johan Oviedo
P
Oviedo is questionable with elbow
Questionable

Endy Rodriguez
IF
Rodriguez is out with elbow
Out
Jared Jones
P
Jones is out with elbow
Out

Keegan Thompson
P
Thompson is out with inactive
Out
Noelvi Marte
IF
Marte is day-to-day with side
Day-to-Day
Brandon Williamson
P
Williamson is out for season with elbow
Out for Season
Graham Ashcraft
P
Ashcraft is out with groin
Out
Chase Burns
P
Burns is out with hip
Out
Julian Aguiar
P
Aguiar is out for season with elbow
Out for Season
Rhett Lowder
P
Lowder is out with elbow
Out
Carson Spiers
P
Spiers is out with shoulder
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Ashcraft, P	72	4.1	5	2
RK.Nicolas, P	24	1.2	3	0
RC.Mlodzinski, P	26	2	0	0

HITTERS	H-AB	R	RBI
1J.Triolo, 3B	0-4	0	0
2N.Gonzales, SS	0-4	0	0
3B.Reynolds, RF	1-4	0	0
4A.McCutchen, DH	0-4	0	0
5T.Pham, LF	1-3	0	0
6J.Bart, C	0-3	0	0
7A.Canario, CF	0-2	0	0
7S.Horwitz, PH	1-1	1	0
7S.Horwitz, 1B	1-1	1	0
8R.Flores, 1B	0-2	0	0
8J.Suwinski, PH	0-1	0	0
8J.Suwinski, CF	0-1	0	0
9N.Yorke, 2B	0-2	0	1

PITCHER	PC	IP	K	ER
LN.Lodolo, P	81	6.1	12	0
RG.Ashcraft, P	8	0.2	1	0
RT.Santillan, P	16	1	1	1
RE.Pagan, P	7	1	0	0

HITTERS	H-AB	R	RBI
1T.Friedl, CF	2-3	1	0
2N.Marte, RF	1-4	1	1
3G.Lux, 2B	2-4	0	1
3M.McLain, 2B	0-0	0	0
4S.Steer, 1B	0-4	0	0
5E.De La Cruz, SS	0-4	0	0
6M.Andujar, DH	2-4	0	0
7W.Benson, LF	1-3	0	0
8J.Trevino, C	0-3	0	0
9K.Hayes, 3B	2-3	0	0