Reds vs. Guardians Odds & Betting Predictions - February 21, 2026

Reds at Guardians

8:05 pm

Cincinnati Reds

@

Cleveland Guardians

MatchupOpenSpreadTotalMoneyline
Reds 0-2	N/A	N/A	N/A
Guardians 1-2	N/A	N/A	N/A

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Saturday 8:05 p.m.

February 21, 2026

Goodyear BallparkGoodyear

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MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 37 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	86-76	39-42	47-34	33-36	51-38
Reds	82-78	40-39	42-39	29-43	53-34

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	69-87-6	37-41-3	32-46-3	34-34-1	34-50-5
Reds	58-91-11	26-45-8	32-46-3	20-47-5	37-44-6

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	88-74	45-36	43-38	44-25	43-46
Reds	83-79	44-35	38-43	39-33	43-44

date	opponent	score	spread	over/under	moneyline
Oct 2nd	DET	L 3-6	-1.5 L	O 7	DET -130
Oct 1st	DET	W 6-1	-1.5 W	U 7	CLE -134
Sep 30th	DET	L 1-2	+1.5 W	U 6	DET +143
Sep 28th	TEX	W 9-8	-1.5 L	O 7.5	CLE -146
Sep 27th	TEX	W 3-2	-1.5 L	U 7.5	CLE -154

Noelvi Marte
RF
Marte is day-to-day with side
Day-to-Day
Brandon Williamson
SP
Williamson is out for season with elbow
Out for Season
Graham Ashcraft
RP
Ashcraft is out with groin
Out
Chase Burns
SP
Burns is out with hip
Out
Julian Aguiar
SP
Aguiar is out for season with elbow
Out for Season
Rhett Lowder
SP
Lowder is out with elbow
Out

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MatchupOverUnder
Reds 0-2	N/A	N/A
Guardians 1-2	N/A	N/A