Cardinals vs. Reds Odds & Betting Predictions - May 22, 2026

Cardinals at Reds

10:40 pm • CINR

St. Louis Cardinals

0

0 - 0

Cincinnati Reds

0

pitcher		team	era	w-l
C.Paddack			5.40	0-2
K.Leahy			4.26	5-3

MatchupOpenSpreadTotalMoneyline
Cardinals 31-27	N/A	N/A	N/A
Reds 30-29	N/A	N/A	N/A

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Friday 10:40 p.m.

May 22, 2026

Great American Ball ParkCincinnati

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MLB Public Betting

Reds are 1-4 in their last 5 games.
Reds are 1-4 in their last 5 games against the spread
Reds are 18-11 in their road games against the spread
The totals have gone OVER in 3 of Reds' last 5 games
The totals have gone OVER in 21 of Reds' 30 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Reds	33-26	15-15	18-11	11-8	22-18
Cardinals	35-23	18-12	17-11	4-3	31-20

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Reds	37-21-1	21-9	16-12-1	13-6	24-15-1
Cardinals	24-31-3	14-15-1	10-16-2	2-5	22-26-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Reds	30-29	15-15	15-14	11-8	19-21
Cardinals	31-27	15-15	16-12	4-3	27-24

date	opponent	score	spread	over/under	moneyline
May 20th	@PHI	W 9-4	+1.5 W	O 9.5	CIN +129
May 19th	@PHI	W 4-1	+1.5 W	U 8.5	CIN +122
May 18th	@PHI	L 4-5	-1.5 L	U 10	PHI +104
May 17th	@CLE	L 3-10	+1.5 L	O 8.5	CLE +135
May 16th	@CLE	L 4-7	+1.5 L	O 8.5	CLE +125

Hunter Greene
SP
Greene is out with elbow
Out

Lars Nootbaar
LF
Nootbaar is out with heel
Out

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MatchupOverUnder
Cardinals 31-27	N/A	N/A
Reds 30-29	N/A	N/A