Twins vs. Guardians Odds & Betting Predictions - July 21, 2026
Twins at Guardians
10:40 pm • MNNTStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 2.73 | 8-5 | ||
![]() | 2.79 | 1-1 |
Twins at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Twins 49-52 | +1.5 | +1.5-166 | o8-115 | +125 |
Guardians 53-48 | u8.5 | -1.5+139 | u8-107 | -150 |

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Twins vs. Guardians Expert Picks
OldSchool0909
Last 30d: 30-34-0 (+2.9u)
MIN +130
1u
Brian Bitler
Last 30d: 49-55-1 (-18.6u)
MIN +133
3u
Adam Kaufman
Last 30d: 120-107-3 (+7.7u)
CLE -148
1.48u
Frank Ammirante
Last 30d: 328-376-7 (-41.4u)
CLE -152
1.52u
P.Messick o4.5 Ks-164
1.64u
Twins vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Twins vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 3-2 in their last 5 games.
- Guardians are 3-2 in their last 5 games against the spread
- Guardians are 27-24 in their road games against the spread
- The totals have gone OVER in 3 of Guardians' last 5 games
- The totals have gone OVER in 26 of Guardians' 50 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. Twins Injury Updates

Guardians Injuries

Twins Injuries
- Pablo LopezSP
Lopez is out with elbow
Out
- David FestaSP
Festa is out with shoulder
Out
- Travis AdamsSP
Adams is out with triceps
Out
Twins vs. Guardians Starting Lineups
Twins Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
![]() | 1-1 | 2.79 | 1.603 | 10.24 |
| HITTERS | AVG | OBP | SLG | HR |
|---|---|---|---|---|
![]() | .244 | .357 | .319 | 2 |
![]() | .275 | .331 | .576 | 25 |
![]() | .288 | .401 | .540 | 8 |
![]() | .251 | .309 | .427 | 13 |
![]() | .218 | .295 | .395 | 10 |
![]() | .240 | .330 | .369 | 7 |
![]() | .263 | .352 | .352 | 4 |
![]() | .252 | .309 | .429 | 14 |
![]() | .246 | .310 | .408 | 5 |
Guardians Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
![]() | 8-5 | 2.73 | 1.071 | 8.84 |
| HITTERS | AVG | OBP | SLG | HR |
|---|---|---|---|---|
![]() | .238 | .343 | .296 | 1 |
![]() | .271 | .335 | .405 | 9 |
![]() | .286 | .351 | .457 | 11 |
![]() | .182 | .314 | .387 | 11 |
![]() | .194 | .308 | .358 | 6 |
![]() | .246 | .337 | .419 | 9 |
![]() | .232 | .276 | .404 | 5 |
![]() | .285 | .343 | .408 | 3 |
![]() | .222 | .243 | .375 | 2 |
Twins vs. Guardians Odds Comparison
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Twins at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
Twins 49-52 | N/A | N/A |
Guardians 53-48 | N/A | N/A |
























