White Sox vs. Cubs Odds & Betting Predictions - May 16, 2025

White Sox at Cubs

6:20 pm • CHSN

Chicago White Sox

3

3 - 13

Chicago Cubs

13

pitcher		team	era	w-l
C.Horton			3.08	7-4
S.Smith			4.01	3-7

MatchupOpenSpreadTotalMoneyline
White Sox 45-80	+1.5	+1.5-105	o11.5-115	+191
Cubs 70-54	u12.5	-1.5-115	u11.5-110	-231

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Friday 6:20 p.m.

May 16, 2025

Wrigley FieldChicago

CWS +150 (F5)

1u

CWS +0.5 (F5)+100

1u

P.Crow-Armstrong o1.5 Total Bases-125

0.9u

Over 11.5-118

0.85u

White Sox vs. Cubs: Play this +255 Parlay
Mike Ianniello•
May 16, 2025 UTC
4 Home Run Prop Bets & Parlay for Friday
Grant Neiffer•
May 16, 2025 UTC

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No props found

MLB Public Betting

Cubs are 2-3 in their last 5 games.
Cubs are 1-4 in their last 5 games against the spread
Cubs are 30-32 in their road games against the spread
The totals have gone OVER in 0 of Cubs' last 5 games
The totals have gone OVER in 28 of Cubs' 62 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	58-66	28-34	30-32	43-45	15-21
White Sox	71-54	36-26	35-28	0-2	71-52

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	57-60-7	28-30-4	29-30-3	38-45-5	19-15-2
White Sox	56-62-7	32-25-5	24-37-2	0-2	56-60-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	70-54	38-24	32-30	56-32	14-22
White Sox	45-80	26-36	19-44	1-1	44-79

date	opponent	score	spread	over/under	moneyline
May 14th	MIA	L 1-3	-1.5 L	U 7.5	MIA -218
May 13th	MIA	W 5-4	-1.5 L	O 8	CHC -262
May 12th	MIA	W 5-2	-1.5 W	U 8	CHC -257
May 11th	@NYM	L 2-6	+1.5 L	U 8.5	NYM +110
May 10th	@NYM	W 6-5	+1.5 W	O 8.5	CHC +141

Ky Bush
SP
Bush is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

Jameson Taillon
SP
Taillon is out with calf
Out
Michael Soroka
SP
Soroka is out with shoulder
Out
Justin Steele
SP
Steele is out for season with elbow
Out for Season

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PITCHER		PC	IP	K	ER
RS.Smith, P		89	5	5	1
LT.Gilbert, P		13	0.1	1	1
LB.Eisert, P		8	0.1	0	1
RM.Castro, P		24	1.1	2	2
RY.Gomez, P		26	1	0	3

HITTERS	H-AB	R	HR	RBI
1C.Meidroth, SS	2-4	1	0	0
2M.Thaiss, C	0-4	0	0	0
3L.Robert, CF	0-4	0	0	0
4M.Vargas, 3B	4-4	2	2	3
5J.Palacios, RF	1-4	0	0	0
6A.Vaughn, 1B	0-4	0	0	0
7E.Quero, DH	1-4	0	0	0
8J.Rojas, 2B	2-4	0	0	0
9B.Baldwin, LF	1-4	0	0	0

PITCHER		PC	IP	K	ER
RC.Horton, P		79	5	2	3
RD.Palencia, P		14	1	0	0
LC.Thielbar, P		18	1	0	0
RR.Pressly, P		14	1	1	0
RJ.Merryweather, P		9	1	1	0

HITTERS	H-AB	R	HR	RBI
1P.Crow-Armstrong, CF	4-5	2	1	6
2K.Tucker, RF	2-5	1	0	0
3S.Suzuki, LF	2-4	1	0	2
4M.Busch, 1B	1-3	2	0	0
5C.Kelly, C	2-4	2	0	0
6D.Swanson, SS	1-4	0	0	1
6V.Brujan, 3B	0-0	0	0	0
7M.Ballesteros, DH	1-4	2	0	2
8N.Hoerner, 2B	2-5	3	0	1
9J.Berti, 3B	0-3	0	0	0
9N.Lopez, PH	0-2	0	0	0
9N.Lopez, 3B	0-2	0	0	0
9N.Lopez, SS	0-2	0	0	0

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MatchupOverUnder
White Sox 45-80	o4.5-125	u4.5+105
Cubs 70-54	o6.5-110	u6.5-118