White Sox vs. Cubs Odds & Betting Predictions - May 16, 2025

White Sox at Cubs

6:20 pm • CHSN

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Chicago White Sox

@

Chicago Cubs

pitcher		team	era	w-l
C.Horton			0.00	0-0
S.Smith			0.00	0-0

MatchupOpenSpreadTotalMoneyline
White Sox 14-29	+1.5	+1.5-108	o12.5-115	+185
Cubs 25-19	u12.5	-1.5-111	u12.5-105	-225

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Friday 6:20 p.m.

May 16, 2025

Wrigley FieldChicago

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80°Fahrenheit

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15Wind

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MLB Public Betting

Cubs are 3-2 in their last 5 games.
Cubs are 2-3 in their last 5 games against the spread
Cubs are 12-10 in their road games against the spread
The totals have gone OVER in 2 of Cubs' last 5 games
The totals have gone OVER in 14 of Cubs' 22 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	22-22	10-12	12-10	13-12	9-10
White Sox	24-19	11-10	13-9	N/A	24-19

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	25-17-2	14-8	11-9-2	13-11-1	12-6-1
White Sox	19-22-2	11-8-2	8-14	N/A	19-22-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	25-19	12-10	13-9	16-9	9-10
White Sox	14-29	9-12	5-17	N/A	14-29

date	opponent	score	spread	over/under	moneyline
May 14th	MIA	L 1-3	-1.5 L	U 7.5	MIA -218
May 13th	MIA	W 5-4	-1.5 L	O 8	CHC -262
May 12th	MIA	W 5-2	-1.5 W	U 8	CHC -257
May 11th	@NYM	L 2-6	+1.5 L	U 8.5	NYM +110
May 10th	@NYM	W 6-5	+1.5 W	O 8.5	CHC +141

Ky Bush
SP
Bush is out with elbow
Out
Chase Meidroth
2B
Meidroth is day-to-day with thumb
Day-to-Day
Drew Thorpe
SP
Thorpe is out with elbow
Out

Drew Pomeranz
RP
Pomeranz is out with elbow
Out
Justin Steele
SP
Steele is out for season with elbow
Out for Season

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MatchupOverUnder
White Sox 14-29	N/A	N/A
Cubs 25-19	N/A	N/A