White Sox vs. Guardians Odds & Betting Predictions - September 14, 2026

White Sox at Guardians

10:40 pm • CHSN
7 - 3
Starting Pitchers
pitcherteameraw-l
Gavin Williams logoG.WilliamsCleveland Guardians logo3.7614-8
Sean Newcomb logoS.NewcombChicago White Sox logo3.092-5

White Sox at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
White Sox
4-3
+1.5
+1.5-158
o7-118
+151
Guardians
5-6
u7
-1.5+132
u7-102
-182
location pinMonday 10:40 p.m.
September 14, 2026
Progressive FieldCleveland
White Sox vs. Guardians Expert Picks
Sean Zerillo
Sean Zerillo
Last 30d: 134-117-6 (+6.6u)
CLE -150 (F5)
0.38u
Small to -175
Austin Pendergrass
Austin Pendergrass
Last 30d: 80-58-0 (+6.4u)
CLE -148
0.5u
Player Prop Savant
Player Prop Savant
Last 30d: 82-76-0 (-0.1u)
Under 3.5 (F5)-118
1u
Topper
Topper
Last 30d: 106-88-4 (+4.4u)
CWS +140
1.4u
Overachieving Road Dogs (***) Overall: 324-287-0,53% (ROI:16%) Season:14-9-0,61% (ROI:30%) Returning Home After Road Trip vs. Division (FADE) Overall: 361-376-1,49% (ROI:14%) Season:10-17-0,37% (ROI:-18%) #TSA
Wags Wins
Wags Wins
Last 30d: 273-239-3 (+28.2u)
CLE -1.5+155
1u

White Sox vs. Guardians Previews & Analysis

  • McGrath's Pick for White Sox vs Guardians article feature image

    McGrath's Pick for White Sox vs Guardians

    Tanner McGrath•
    Sep 14, 2026 UTC
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Prop Odds Comparison

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White Sox vs. Guardians Public Betting Percentages

Away Logo

White Sox

Public

21%

Bets%

79%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
79-8336-4543-3843-5536-24
White Sox
92-7049-3243-3828-2363-46

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
77-8542-3935-4648-5027-33
White Sox
92-69-145-35-147-3427-23-163-46

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
85-7741-4044-3755-4330-30
White Sox
84-7848-3336-4530-2153-56

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@MINW 9-2+1.5 WO 8CLE +105
Sep 12th@MINL 3-4-1.5 LU 8.5MIN -109
Sep 12th@MINW 5-2-1.5 WU 7.5CLE -119
Sep 9th@BALL 5-9-1.5 LO 8.5BAL -118
Sep 8th@BALW 9-5-1.5 WO 8CLE +104

Guardians vs. White Sox Injury Updates

Guardians Injuries

    White Sox Injuries

    • Mike Vasil
      RP

      Vasil is out with elbow

      Out

    • Ky Bush
      P

      Bush is out with elbow

      Out

    • Brooks Baldwin
      LF

      Baldwin is out with elbow

      Out

    • Drew Thorpe
      SP

      Thorpe is out with elbow

      Out

    White Sox vs. Guardians Box Score
    White Sox Player Stats
    Projected
    PITCHERPCIPKER
    Sean Newcomb logoLS.Newcomb, P13100
    Sean Burke logoRS.Burke, P94540
    Hagen Smith logoLH.Smith, P26230
    Trevor Richards logoRT.Richards, P9100
    HITTERSH-ABRHRRBI
    Sam Antonacci logo1S.Antonacci, LF1-3000
    Randal Grichuk logo1R.Grichuk, PH1-2000
    Randal Grichuk logo1R.Grichuk, LF1-2000
    Brenton Doyle logo1B.Doyle, CF0-0000
    Kyle Teel logo2K.Teel, C1-4102
    Miguel Vargas logo3M.Vargas, 3B2-4212
    Munetaka Murakami logo4M.Murakami, 1B0-3000
    Andrew Benintendi logo5A.Benintendi, DH3-5101
    Luisangel Acuna logo5L.Acuna, PR0-0000
    Luisangel Acuna logo5L.Acuna, DH0-0000
    Tristan Peters logo6T.Peters, CF0-3100
    Tristan Peters logo6T.Peters, LF0-3100
    Colson Montgomery logo7C.Montgomery, SS0-4100
    Chase Meidroth logo8C.Meidroth, 2B1-4101
    Braden Montgomery logo9B.Montgomery, RF0-3000
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Gavin Williams logoRG.Williams, P113571
    Tim Herrin logoLT.Herrin, P180.213
    Daniel Espino logoRD.Espino, P120.111
    Slade Cecconi logoRS.Cecconi, P412.141
    Connor Brogdon logoRC.Brogdon, P140.210
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, CF1-3000
    Steven Kwan logo1S.Kwan, LF1-3000
    Jose Ramirez logo2J.Ramirez, 3B1-4000
    Chase DeLauter logo3C.DeLauter, DH0-3000
    Jo Adell logo4J.Adell, RF1-4100
    Travis Bazzana logo5T.Bazzana, 2B1-4000
    Angel Martinez logo6A.Martinez, LF0-3000
    Daniel Schneemann logo6D.Schneemann, CF0-1000
    Nathaniel Lowe logo7N.Lowe, 1B0-2000
    David Fry logo7D.Fry, PH1-2112
    David Fry logo7D.Fry, 1B1-2112
    Patrick Bailey logo8P.Bailey, C1-4100
    Brayan Rocchio logo9B.Rocchio, SS1-3000

    White Sox vs. Guardians Odds Comparison

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    White Sox at Guardians Team Totals

    MatchupOverUnder
    White Sox
    4-3
    N/A
    N/A
    Guardians
    5-6
    N/A
    N/A