The San Diego Padres host the Athletics on May 22, 2026. First pitch from Petco Park is scheduled for 9:40 p.m. EDT. The game will be broadcast on NBCS-CA.
The Padres are favored by -134 on the moneyline and by -1.5 on the run line. The Athletics are +116 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Athletics vs Padres prediction below, as well as probable pitchers, weather report, and more.
Athletics vs Padres Prediction
- Athletics vs Padres Pick: Jeffrey Springs Over 16.5 Outs
Athletics vs Padres Odds
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -182 | 8 -110o / -110u | +116 |
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +150 | 8 -110o / -110u | -134 |
Athletics vs Padres Probable Pitchers
| Jeffrey Springs (LHP, ATH) | Stat | Walker Buehler (RHP, SDP) |
|---|---|---|
| 3-4 | W-L | 3-2 |
| 0.8 | fWAR (FanGraphs) | 0.6 |
| 3.93 / 3.57 | ERA / xERA | 5.01 / 4.85 |
| 4.26 / 4.32 | FIP / xFIP | 3.73 / 3.73 |
| 13.5% | K-BB% | 12.8% |
| 32.5% | GB% | 44.1% |
| .268 | BABIP | .309 |
| 98 | Stuff+ | 95 |
| 104 | Location+ | 97 |
Athletics vs Padres MLB Betting Preview
Jeffrey Springs is the anti-Eury Perez. He is a significantly better pitcher on the road compared to at home. Springs has an ERA under 3.50 since 2025 on the road, while his ERA on the road is above 4.50.
Despite better results on the road, Springs' K-BB is better at home. As a heavy flyball pitcher (46.6%), he cannot rely on weak contact in the hitter-friendly confines of Sacramento's home park (second-highest park factor).
In a pitcher-friendly stadium like Petco Park (fourth-lowest park factor), Springs can be at ease on the mound and play his game.
Athletics vs Padres Pick, Betting Analysis
The Padres rank worst in baseball with a .265 wOBA against LHP and second-worst by their 69 wRC+. While their walk rate vs LHP is fourth-worst, their strikeout rate is ninth-highest.
Assuming Springs continues to keep his strikeouts on the road low, he should command enough easy outs to get past the line on his outs.
Pick: Jeffrey Springs Over 16.5 Outs
