The Chicago Cubs host the Baltimore Orioles on August 1, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET; the game will be broadcast on MASN2.
Find my MLB betting preview and Orioles vs Cubs prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Orioles vs Cubs Prediction
- Orioles vs Cubs pick: Orioles ML +130
My Orioles vs Cubs best bet is on the Orioles moneyline. Make sure to find the best odds by checking our live MLB odds page.
Orioles vs Cubs Odds
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -169 | 7 -113o / -108u | +129 |
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +138 | 7 -113o / -108u | -158 |
Orioles vs Cubs Prediction, Betting Analysis
The Orioles produced 27 runs across their first two games of a four-game set against the Blue Jays earlier this week. In fact, they won three of the four matchups against Toronto, losing the final duel by only one run (9-8).
They also scored 18 runs on July 26 against the Rockies, so the offense has been producing as of late.
However, Baltimore is still nine games under .500 and in last place in the AL East.
Now it has to play a Cubs team that's 18 games above .500 and just one game back from the Brewers for the NL Central lead. Chicago also leads the wild card race in the National League, but not by much.
Regardless, the pick is on the Orioles, especially with this system lighting up.
Evan Abrams' "Road Dogs Interleague" system is spotlighting the Orioles on moneyline as the best bet for this matchup.
In interleague matchups early in a series, road underdogs often hold unseen advantages. These games introduce travel and scouting uncertainty, and early games feature lineups and matchups unfamiliar to bettors and models.
Public perception tends to lean too heavily on home-field advantage.
Interleague games introduce more unpredictability due to differences in lineup construction and unfamiliar opposing pitchers.
When combined with road 'dog pricing, it creates exploitable inefficiencies in early matchups — and that's what we have here.
Most importantly, this system has a positive overall ROI (2.1%) since its inception in 2016.
Pick: Orioles ML +130
Moneyline
The play is on the Orioles moneyline as the road underdog.
Run Line (Spread)
There's no bet on the run line for this Orioles vs. Cubs affair.
Over/Under
There's also no value on the total in this matchup.
Orioles vs Cubs Betting Trends
