The St. Louis Cardinals host the Chicago Cubs on Wednesday, June 25, 2025. First pitch from Busch Stadium is scheduled for 7:45 p.m. ET; the game will be broadcast on FanDuel Sports Midwest and Marquee Sports Network.
St. Louis will look to earn another key win over Chicago on Wednesday when Matthew Boyd (2.84 ERA, 85 and 2/3 IP) takes on Erick Fedde (3.54 ERA, 84 IP). The Cardinals have cut the Cubs' lead in the division to 2 1/2 games with wins in the first two games of the series.
Find my Cubs vs Cardinals prediction below, as well as Wednesday probable pitchers, betting trends and more.
My Cubs vs Cardinals Prediction
- Cubs vs Cardinals picks: Cubs Run Line -1.5 +112 (FanDuel, Play to +107)
My Cubs vs Cardinals best bet is Cubs -1.5 +112. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Cardinals Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +106 | 8.5 -122o / -100u | -148 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -128 | 8.5 -122o / -100u | +126 |
Cubs vs Cardinals Projected Starting Pitchers
| LHP Matthew Boyd (CHC) | Stat | RHP Erick Fedde (STL) |
|---|---|---|
| 6-3 | W-L | 3-6 |
| 1.6 | fWAR (FanGraphs) | 1.0 |
| 2.84/3.56 | ERA /xERA | 3.54/4.99 |
| 3.66/3.99 | FIP / xFIP | 4.06/4.93 |
| 1.14 | WHIP | 1.30 |
| 16.8% | K-BB% | 5.4% |
| 36.0% | GB% | 39.7% |
| 96 | Stuff+ | 91 |
| 105 | Location+ | 105 |
Nick Martin’s Cubs vs Cardinals Preview
Chicago Cubs Betting Preview: Boyd On Fire
After his side allowed 16 runs over the first two games of this rivalry series, Craig Counsell will be happy to send Boyd to the mound to start Wednesday's matchup. Boyd holds a 2.84 ERA and 3.56 xERA this season, and has allowed two earned runs or less in five consecutive starts.
In his last five starts, Boyd holds a 3.44 FIP and a minuscule WHIP of 0.83. He's struck out 20.9% of batters and allowed soft contact 19.1% of the time.
The Cubs' defensive play has been surprisingly sloppy in the first two matchups of this series, but has generally been excellent this season. They rank sixth in fielding percentage and ninth in Outs Above Average this season.
Chicago has been one of the most productive lineups in baseball against right-handed pitching this season, currently ranking fourth with a wRC+ of 116 and a slugging percentage of .443. Miguel Amaya remains the only position player on the IL, and it's a safe bet that it will field its best lineup in this interdivision matchup.
St. Louis Cardinals Betting Preview: Underlying Concerns for Fedde
Fedde has emerged as a potential trade candidate after his solid start to the season, as plenty of contenders are looking to add reliable arms to the back end of the rotation. The Cardinals may be wise to ship him out sooner rather than later, as Fedde does look likely to regress in the near future.
Fedde holds a 4.99 xERA and 4.93 xFIP this season and a career low ground-ball rate of 39.1%. Pitch metrics are also low on Fedde, as he holds a Stuff+ rating of 91 and a Pitching+ rating of 98. In his last five starts, Fedde holds a strong 3.04 ERA, but his underlying results have been much less convincing, as he holds a 4.57 xFIP, 34.6% ground-ball rate, and Pitching+ rating of 96.
The Cardinals have hit to lesser splits versus lefties this season, as they hold a wRC+ rating of 97 and rank 28th in hard-hit rate.
Cubs vs Cardinals Prediction, Betting Analysis
This looks like a good spot to back the Cubs getting it right with an important win, as they look to prevent the Cardinals from cutting any further into their lead atop the NL Central. Boyd has achieved better results where it counts this season compared to Fedde and enters this matchup with a much more convincing underlying profile.
The Cubs have been dominant against right-handed pitching this season and should continue to find success with what has become a deep and scrappy lineup. The Cardinals have been significantly less productive versus left-handed pitching this season, and Boyd should have a good opportunity to author another quality start.
At +108 or better, there looks to be value in backing the Cubs to cover the run line in this matchup.
Pick: Cubs Run Line -1.5 +112 (FanDuel, Play to +108)
Moneyline
Betting the Cubs to win the game at -150 is another strong way to bet this game and would obviously be my preferred bet in terms of backing the moneyline.
Run Line (Spread)
As outlined, betting on the Cubs to cover the run line is my favorite play from this matchup.
Over/Under
My lean would be to bet on the game going over 8.5 in terms of the total, as my greater faith lies in backing the Cubs to do some significant damage against Fedde.
