The Athletics host the Houston Astros on September 25, 2025. First pitch from Sutter Health Park is scheduled for 3:35 p.m. EDT; the game will be broadcast on SCHN.
After losing the first two games of the series, the Astros must avoid a sweep that could push them further away from playoff contention.
Find my MLB betting preview and Astros vs Athletics prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Astros vs Athletics Prediction
- Astros vs Athletics pick: Under 9.5 (-115)
My Astros vs Athletics best bet is Under 9.5 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Astros vs Athletics Odds
| Astros Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +135 | 9.5 -105o / -115u | -115 |
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -160 | 9.5 -105o / -115u | -105 |
Astros vs Athletics Projected Starting Pitchers
| LHP Framber Valdez (HOU) | Stat | RHP J.T. Ginn (ATH) |
|---|---|---|
| 12-11 | W-L | 4-6 |
| 3.8 | fWAR (FanGraphs) | 0.7 |
| 3.75 / 3.80 | ERA / xERA | 4.57 / 3.71 |
| 3.39 / 3.41 | FIP / xFIP | 4.64 / 3.40 |
| 1.24 | WHIP | 1.32 |
| 14.4 | K-BB% | 18.1 |
| 58.3 | GB% | 53.5 |
| 108 | Stuff+ | 97 |
| 99 | Location+ | 108 |
Astros vs Athletics Preview
The first two games of this series have already hit the under despite the favorable hitting conditions at Sutter Health Park.
The Astros have entered a serious slump at the worst possible moment, losing the division title and putting their playoff spot at risk. They have scored just 13 runs in their past six games, averaging 2.16.
The Athletics haven't produced a ton lately. After the Pirates shut them out twice in a row, the A's scored five and six runs in the first two games of this series, which means an average of 2.75 runs in their last four contests.
The A's lineup does a bit worse when facing left-handed pitchers, which could help Astros starter Framber Valdez with his recent struggles.
J.T. Ginn will get the ball for the home team, and he's had success against Houston in 2025. In his last matchup, the right-hander held them scoreless through six innings, giving up only three hits. Plus, Ginn has a 3.55 ERA in day games this season.
Our Bet Labs recommendation is to stay with the under for this series finale.
This system targets unders in regular-season MLB games where softer home starting pitchers — low strikeout rates and moderate WHIP — are on the mound in games three or four of a series.
By this point in the series, hitters have seen multiple arms, and scouting reports are sharper, yet scoring remains muted when the matchup lacks overpowering velocity and winds remain neutral.
The setup avoids exaggerated run environments by filtering out strong directional wind influence, keeping offensive surges in check.
With the home team in the middle of the season grind, winning at a modest clip, the market may overlook how often these quiet conditions lead to slower-paced, low-scoring outcomes.
Pick: Under 9.5 (-115, bet365)
Astros vs Athletics Betting Trends
