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Mets vs Cubs Prediction, Pick, Odds for Thursday, September 25

Mets vs Cubs Prediction, Pick, Odds for Thursday, September 25 article feature image
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Photo by Eric Hartline-Imagn Images. Pictured: Nolan McLean

The Chicago Cubs host the New York Mets on September 25, 2025. First pitch from Wrigley Field is scheduled for 7:40 p.m. EDT; the game will be broadcast on SNY.

The Mets are trying to hold onto their one-game lead for the last spot in the NL Wild Card race, and this series finale is a must-win game for them.

Find my MLB betting preview and Mets vs Cubs prediction below, as well as probable pitchers, betting trends, injury reports and more.

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My Mets vs Cubs Prediction

  • Mets vs Cubs pick: Under 7.5 (-115)

My Mets vs Cubs best bet is Under 7.5 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.


Mets vs Cubs Odds

Mets Logo
Thursday, Sep 25
7:40 p.m. ET
SNY
Cubs Logo
Mets Odds
SpreadTotalMoneyline
-1.5
+150
7.5
-105o / -115u
-115
Cubs Odds
SpreadTotalMoneyline
+1.5
-180
7.5
-105o / -115u
-105
Odds via bet365. Get up-to-the-minute MLB odds here.
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Mets vs Cubs Projected Starting Pitchers

RHP Nolan McLean (NYM)StatLHP Shota Imanaga (CHC)
4-1W-L9-7
1.4fWAR (FanGraphs)1.0
1.27 / 3.32ERA / xERA3.37 / 4.07
2.41 / 2.94FIP / xFIP4.77 / 4.47
1.01WHIP0.96
19.4K-BB%16.5
64.1GB%28.8
116Stuff+94
94Location+108

Mets vs Cubs Preview

Mets rookie Nolan McLean has not allowed more than two runs in any of his seven starts this season, with a 1.27 ERA and 46 strikeouts through 42 and 2/3 innings so far.

McLean has given up a total of just two earned runs in his past three outings combined and will look to shut down a Cubs offense that has produced 17 runs in the first two games of this series.

Shota Imanaga will oppose him for Chicago. The lefty has a 3.29 ERA at home this season, and will face a Mets lineup that performs significantly worse against southpaws, going from 4th overall in wRC+ (113) to 15th versus LHP (97).

The Mets have also struggled a bit lately, ranking 10th in the majors in wRC+ in the past two weeks.

Our Bet Labs system recommends going against the trend and backing the under tonight.

MLB Icon
Evan Abrams – Contrarian Unders for Winning Teams, Later in Series
the game is played during the Regular or Postseason season
betting on the Under
the home team's win percentage is between 51% and 100%
the visitor team's win percentage is between 51% and 100%
the over/under % is between 0% and 35%
the series game # is between 2 and 100
$13,644
WON
1385-1180-110
RECORD
54%
WIN%

This system targets unders in MLB series games (Game 2 or later) where both teams have winning records, suggesting quality pitching and competitive matchups.

However, public betting leans toward the over — likely expecting fireworks between top teams — which creates contrarian value on the under.

By capitalizing on low public support for the under (≤35%), the strategy fades public perception in favor of market inefficiencies, especially when bettors overestimate offensive output late in a series.

Pick: Under 7.5 (-115, bet365)


Mets vs Cubs Betting Trends


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