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Yankees vs Astros Prediction, Pick, MLB Odds for Sunday, April 26

Yankees vs Astros Prediction, Pick, MLB Odds for Sunday, April 26 article feature image
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Pictured: New York Yankees pitcher Luis Gil. (Credit: David Butler II-Imagn Images)

The Houston Astros host the New York Yankees on April 26, 2026. First pitch from Daikin Park is scheduled for 2:10 p.m. EDT. The game will be broadcast on SCHN.

The Yankees are favored by -140 on the moneyline and by -1.5 on the run line. The Astros are +118 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.

Find our MLB picks and Yankees vs Astros prediction below, as well as probable pitchers, weather report, and more.


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Yankees vs Astros Prediction

  • Yankees vs Astros Pick: Astros +1.5 (-135)

Our Yankees vs Astros best bet is to take Houston on the runline. Make sure to find the best odds by checking our live MLB odds page.


Yankees vs Astros Odds

Yankees Logo
Sunday, Apr 26
2:10 p.m. ET
SCHN
Astros Logo
Yankees Odds
SpreadTotalMoneyline
-1.5
+105
9.5
-115o / -105u
-140
Astros Odds
SpreadTotalMoneyline
+1.5
-135
9.5
-115o / -105u
+118
Odds via BetMGM. Get up-to-the-minute MLB odds here.
BetMGM Logo
  • Yankees vs Astros moneyline: Yankees -140, Astros +118
  • Yankees vs Astros over/under: 9.5 (-115o / -105u)
  • Yankees vs Astros spread: Yankees -1.5 (+105), Astros +1.5 (-135)

Yankees vs Astros Probable Pitchers

RHP Luis Gil (NYY)StatRHP Spencer Arrighetti (HOU)
1-1W-L2-0
-0.2fWAR (FanGraphs)0.2
4.11/5.25ERA / xERA2.45/5.08
7.32/5.90FIP / xFIP3.79/5.22
1.5%K-BB%9.6%
42.2%GB%39.3%
.143BABIP.286
95Stuff+97
88Location+85

Yankees vs Astros MLB Betting Preview

The New York Yankees arrive at the third game of this series riding a wave of immense momentum, seeking to extend their current eight-game winning streak.

New York has asserted its dominance in the opening matchups, securing a 12-4 victory in the series opener followed by an 8-3 win on Saturday night. That second contest was highlighted by Austin Wells, who delivered a critical tiebreaking home run in the seventh inning to help pull the Yankees away and keep their streak alive.

Entering Sunday's finale, the Yankees sit comfortably at 18-9, maintaining a strong position in the AL East, while the Houston Astros continue to struggle, holding a 10-18 overall record and sitting fifth in the AL West.

Sunday’s pitching matchup features Luis Gil for New York, who enters with a 1-1 record, a 4.11 ERA, and 1.17 WHIP across his appearances, looking to maintain the pitching standard set by his teammates.

The Astros will counter with Spencer Arrighetti, who has been a bright spot on the mound for Houston, boasting a 2-0 record with a sharp 2.45 ERA and 13 strikeouts.


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Yankees vs Astros Pick, Betting Analysis

For this matchup, the recommended play is to take the Houston Astros on the +1.5 runline.

This selection is supported by the #PRO: Contrarian Runline against Elite Teams" system, which focuses on identifying value in backing teams as underdogs against elite opponents—defined as those with a win rate of 60% or higher—in non-division matchups.

The Yankees clearly qualify as an elite team given their current standing and impressive winning streak.

Market dynamics often favor strong favorites like New York, creating a public bias that frequently inflates the line against the underdog.

Because this is a non-division game, the lack of intense familiarity between these two clubs often leads to lower-scoring, tighter contests where the underdog has a significantly higher probability of covering the spread.

With the public heavily leaning toward the hot Yankees, the runline on Houston presents an excellent opportunity to capitalize on a potential backdoor cover or a close game decided by a single run.

Expect Arrighetti to keep the Astros within striking distance and facilitate a cover against the heavily backed Yankees.

Pick: Astros +1.5 (-135)

Playbook

Yankees vs Astros Weather


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