The Cincinnati Reds host the San Francisco Giants on April 14, 2026. First pitch from Great American Ball Park is scheduled for 6:40 p.m. EDT. The game will be broadcast on NBCS-BA.
The Giants are favored by -106 on the moneyline and by -1.5 on the run line. The Reds are -110 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find my MLB picks and Giants vs Reds prediction below, as well as probable pitchers, weather report, and more.
Giants vs Reds Prediction
- Giants vs Reds Pick: Rafael Devers Home Run
Giants vs Reds Odds
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +150 | 9 -105o / -115u | -106 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -182 | 9 -105o / -115u | -110 |
Giants vs Reds MLB Betting Preview
San Francisco Giants Home Run Picks
While Brady Singer has been reliable over the past few years, he is off to a miserable start in 2026, posting a 7.71 ERA over his first two outings.
I am very concerned about Singer's lackluster start to the season as he has struggled mightily with both velocity and command.
Given that both players used to play in the American League, Rafael Devers and Singer have squared off 11 times, with the Giants’ superstar getting the upper hand with four hits and a homer.
The Reds’ right-hander has shown great vulnerability to allowing homers with his sinker when he loses command and velocity, both of which have been problematic for Singer thus far.
While his sinker used to be very effective, mostly allowing contact via ground balls, his drastic drop in velocity in 2026 has made his favorite pitch very flat, making it more prone to hard contact.
There is no doubt that Devers has had consistency issues behind the plate after getting moved from the Red Sox at the 2025 trade deadline, which has continued into this season as the Giants’ star has only just hit his second homer of the season.
That said, I think this is a prime spot for Devers on Tuesday.
In addition to the Reds’ Great American Ballpark being the second most common park in the MLB when it comes to allowing long homers (behind just Coors Field), Singer has struggled mightily AGAINST left-handed power hitters like Devers.
Devers is also an elite "bad-ball hitter," frequently smashing moonshots against breaking and off-speed stuff down in the zone, which is where Singer likes to throw his sinker.
Given Singer’s command issues, I think it is very possible he leaves an off-speed pitch low in the zone where Raffy has thrived on launching homers for the entirety of his career.
Dever’s exceptional ability to cover the entire plate and launch lower-zone off-speed pitches could be very problematic for the Cincinnati righty.
Despite a rather slow start to the season, the Giants’ lefty has a prime matchup on Tuesday.
Pick: Rafael Devers Home Run
