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Mariners vs Twins Prediction, Pick, MLB Odds for Wednesday, April 29

Mariners vs Twins Prediction, Pick, MLB Odds for Wednesday, April 29 article feature image
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Photos Courtesy of Imagn Images. Pictured: Julio Rodriguez (left), Byron Buxton (right).

The Minnesota Twins host the Seattle Mariners on April 29, 2026. First pitch from Target Field is scheduled for 1:40 p.m. EDT. The game will be broadcast on SEAM.

The Mariners are favored by -126 on the moneyline and by -1.5 on the run line. The Twins are +108 on the moneyline and +1.5 on the run line. The total is set at 8 runs.

Find my MLB picks and Mariners vs Twins prediction below, as well as probable pitchers, weather report, and more.


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Mariners vs Twins Prediction

  • Mariners vs Twins Pick: Mariners ML (-130 or Better)

My Mariners vs Twins best bet is on Seattle to win. Make sure to find the best odds by checking our live MLB odds page.


Mariners vs Twins Odds

Mariners Logo
Wednesday, Apr 29
1:40 p.m. ET
SEAM
Twins Logo
Mariners Odds
SpreadTotalMoneyline
-1.5
+136
8
-105o / -115u
-126
Twins Odds
SpreadTotalMoneyline
+1.5
-164
8
-105o / -115u
+108
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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  • Mariners vs Twins moneyline: Mariners -126, Twins +108
  • Mariners vs Twins over/under: 8 (-105o / -115u)
  • Mariners vs Twins spread: Mariners -1.5 (+136), Twins +1.5 (-164)

Mariners vs Twins Pitchers

George Kirby (RHP, SEA)StatTaj Bradley (RHP, MIN)
4-2W-L3-1
0.6fWAR (FanGraphs)0.6
2.97 / 2.85ERA / xERA2.91 / 4.25
3.82 / 3.81FIP / xFIP3.81 / 4.06
13.1%K-BB%16.3%
58.4%GB%35.1%
.257BABIP.297
99Stuff+107
113Location+90

Mariners vs Twins MLB Betting Preview

This game triggered one of our Action PRO betting systems, powered by Evan Abrams.

The Road Tilt in the Dead Heat system targets MLB regular-season games in which two evenly matched teams (based on win percentage) meet in a non-divisional setting, and one is quietly priced as a modest road favorite.

When there's no clear performance gap, but the market still tilts slightly toward the road team, it suggests underlying confidence from oddsmakers that may not be reflected in public perception.

This model seizes those subtle cues, leaning into the narrow value created by near-identical records and overlooked road strength.


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Mariners vs Twins Pick, Betting Analysis

While the Mariners aren't off to the hottest start, I'm still a firm believer that they have the highest upside of any American League squad.

Meanwhile, the Twins are starting to come back to Earth after their scorching hot start.

I am banking on more two-way regression on Wednesday.

Pick: Mariners ML (-130 or Better)

Playbook

Mariners vs Twins Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Tanner McGrath covers college basketball, college football and Major League Baseball at Action Network. He is a contributor to Payoff Pitch, Action Network’s Major League Baseball betting podcast. He's been working in the space for more than five years with past journalism experience in Canadian collegiate sports, finance and economics. He has an obsession with America East basketball, betting the Miami Marlins and sweating out home underdogs.

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