The St. Louis Cardinals host the Seattle Mariners on April 25, 2026. First pitch from Busch Stadium is scheduled for 2:15 p.m. ET. The game will be broadcast on SEAM.
The Mariners are favored by -148 on the moneyline and by -1.5 on the run line. The Cardinals are +126 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Mariners vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Mariners vs Cardinals Prediction
- Mariners vs Cardinals Pick: Mariners ML (-148, Play to -165)
My Mariners vs Cardinals best bet is on Seattle to win outright. Make sure to find the best odds by checking our live MLB odds page.
Mariners vs Cardinals Odds
| Mariners Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +118 | 7.5 -105o / -115u | -148 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -142 | 7.5 -105o / -115u | +126 |
- Mariners vs Cardinals moneyline: Mariners -148, Cardinals +126
- Mariners vs Cardinals over/under: 7.5 (-105o / -115u)
- Mariners vs Cardinals spread: Mariners -1.5 (+118), Cardinals +1.5 (-142)
Mariners vs Cardinals Probable Pitchers
| RHP Bryan Woo (SEA) | Stat | LHP Matthew Liberatore (SL) |
|---|---|---|
| 1-2 | W-L | 0-1 |
| 1.2 | fWAR (FanGraphs) | -0.1 |
| 2.25 / 2.47 | ERA / xERA | 3.67 / 4.69 |
| 2.26 / 4.26 | FIP / xFIP | 5.46 / 5.06 |
| 16.3 | K-BB% | 5.1 |
| 34.8 | GB% | 37.8 |
| .247 | BABIP | .267 |
| 109 | Stuff+ | 100 |
| 108 | Location+ | 100 |
Mariners vs Cardinals MLB Betting Preview
Mariners vs Cardinals Pick, Betting Analysis
Seattle came one game shy of making the World Series a season ago — and now they find themselves as the most disappointing team in MLB. They sit at 12-15 after beating the Cardinals in Game 1.
Bryan Woo draws the start for the road team. He's an absolute stud Cy Young candidate, boasting a 2.25 ERA with a 2.48 xERA and a 2.27 FIP. He also limits the opponent to a .204 batting average and walks hitters 4% of the time.
Action PRO projects Woo for 5.1 strikeouts this afternoon.
The Mariners' offense is still pretty strong, ranking 13th in MLB with a 102 wRC+. The good thing? It should only improve from here, as Julio Rodriguez and Cal Raleigh are too good of hitters to have posted a wRC+ below 100.
Their plate approach can be dicey at times. They strike out 24% of the time and walk 10% of the time. Pitchers end up leaving the game early due to deep pitch counts with all the strikeouts and walks, but it doesn’t always equate to scoring.
The fans in St. Louis must be excited with their team posting a 14-11 record to start the season. This was supposed to be a rebuilding season for the Cardinals, but the emergence of Jordan Walker and JJ Wetherholt has made them competitive.
The breakout leap for Matthew Liberatore has yet to happen. The tall southpaw has a 3.67 ERA, a 4.69 ERA, and a 5.48 xERA. He just needs so much to go his way to have a good outing due to his 5.33 K/9. Pinpoint command held Liberatore above water last year, but his walk rate increased from 6% to 13%.
I touched on Walker earlier, and he's been the engine for the Cardinals' offense, which ranks 20th in wRC+. The league has responded to Walker's hot streak, and he's hitting just .172 in the last week. Wetherholt is hitting just .220 this year, but his .360 OBP makes him tough at the plate.
Three other hitters — Ivan Herrera, Alec Burleson, and Masyn Winn each have a wRC+ better than 110. That has helped stabilize this Cardinals lineup in the last week, with Walker hitting a cold spell.
Long-term, my worry is power. Walker accounts for eight of the Cardinals' 27 home runs, and nobody else has more than three. With Walker's cold spell, who else can come up with a timely hit and provide some pop?
I just think the Cardinals are performing above their level right now. Walker will get hot again, but can he replicate his performance from earlier? Probably not. Plus, the pitching is a problem. Liberatore likely only goes five or six innings at most, which will expose a shaky Cardinals bullpen.
The advantage lies with the Mariners in the starting pitching department with Woo over Liberatore. I also have more faith in the Mariners' lineup to hit Liberatore, who will face regression soon enough. With the line sitting at Seattle -148, it's still plenty good enough to take them with its ace on the hill.
Pick: Mariners ML (-148, FanDuel | Play to -165)
