The Cincinnati Reds (16-13) host the St. Louis Cardinals (12-17) on Wednesday, April 30, 2025. First pitch for the first game of the Reds-Cardinals doubleheader from Great American Ball Park is scheduled for 12:40 p.m. ET; the game will be broadcast on FanDuel Sports Midwest/Ohio.
Originally slated to start on Tuesday, Miles Mikolas and Brady Singer will instead start on Wednesday afternoon.
Find my Cardinals vs Reds prediction for Wednesday below, as well as probable pitchers, betting trends and more.
Editor's Note: This Cardinals vs Reds betting preview was originally published on Tuesday before the game was postponed due to inclement weather.
My Cardinals vs Reds Prediction
- Cardinals vs Reds picks: Cardinals ML (+125, BetMGM)
My Cardinals vs Reds best bet is on the Cardinals moneyline. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Reds Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -175 | 9.5 -110o / -110u | +125 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +145 | 9.5 -110o / -110u | -140 |
Cardinals vs Reds Projected Starting Pitchers
| RHP Miles Mikolas (STL) | Stat | RHP Brady Singer (CIN) |
|---|---|---|
| 0-2 | W-L | 4-0 |
| 0.6 | fWAR (FanGraphs) | 0.7 |
| 5.70 / 4.65 | ERA /xERA | 3.62 / 2.98 |
| 3.11 / 5.05 | FIP / xFIP | 3.14 / 3.24 |
| 1.52 | WHIP | 1.13 |
| 3.8% | K-BB% | 20.5% |
| 39.3% | GB% | 32.4% |
| 89 | Stuff+ | 95 |
| 107 | Location+ | 102 |
Nick Galaida’s Cardinals vs Reds Prediction and Pick
Reds starting pitcher Brady Singer is a fly-ball oriented pitcher (32% ground-ball rate) who has been surrendering a lot of hard contact early in the season.
The Cardinals' offense should be able to get to him for some runs.
Cardinals starting pitcher Miles Mikolas isn't a great option to trust in most spots, but he still gets enough ground balls (40%) to give him a chance to be lucky once in a while.
If he can keep the ball on the ground more often than Singer, the Cardinals should have a good shot in the latter frames to cash as road ‘dogs — Cincinnati's bullpen looks quite shaky, ranking 28th among MLB teams in reliever FIP (4.78).
Pick: Cardinals ML (+125, BetMGM)
