The Detroit Tigers host the St. Louis Cardinals on April 5, 2026. First pitch from Comerica Park is scheduled for 7:20 p.m. EDT. The game will be broadcast on Peacock.
The Tigers are favored by -136 on the moneyline and by -1.5 (+155) on the run line. The Cardinals are +116 on the moneyline and +1.5 (-188) on the run line. The total is set at 8 runs.
Find my MLB picks and Cardinals vs Tigers prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Tigers Prediction
- Cardinals vs Tigers Pick: Cardinals F5 ML (+104)
My Cardinals vs Tigers best bet is on St. Louis' F5 moneyline. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Tigers Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -188 | 8 -110o / -110u | +116 |
| Tigers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 8 -110o / -110u | -136 |
- Cardinals vs Tigers spread: Cardinals +1.5 (-188), Tigers -1.5 (+155)
- Cardinals vs Tigers over/under: 8 (-110o / -11ou)
- Cardinals vs Tigers moneyline: Cardinals (+116), Tigers (-136)
Cardinals vs Tigers Projected Starting Pitchers
| RHP Kyle Leahy (STL) | Stat | RHP Keider Montero (DET) |
|---|---|---|
| 0-1 | W-L | 5-3 (2025 Stats) |
| 0.0 | fWAR (FanGraphs) | 0.1 |
| 7.20 / 8.76 | ERA /xERA | 4.37 /4.65 |
| 3.98 / 5.46 | FIP / xFIP | 4.93 / 4.46 |
| 2.00 | WHIP | 1.39 |
| -4.2 | K-BB% | 10.5 |
| 52.4 | GB% | 41.5 |
| 92 | Stuff+ | 97 |
| 112 | Location+ | 101 |
Cardinals vs Tigers Preview
St. Louis Cardinals
The Cardinals are trying to avoid the sweep against the Tigers.
St. Louis sends out right-hander Kyle Leahy for this game.
This is a converted reliever who struggled in his season debut, allowing four runs on eight hits with two walks and one strikeout in five innings against the Mets.
However, it's worth noting that Leahy was effective last season, putting up a 3.73 SIERA and 14.3 K-BB%.
This could be a spot for a bounce-back in a pitcher-friendly environment like Comerica Park.
Detroit Tigers
The Tigers were swept on the road vs. the Diamondbacks.
Now, they're trying to erase that with a sweep of their own at home against the Cardinals.
With Justin Verlander on the injured list with a hip issue, they've called up Keider Montero to make a spot start.
This is an underwhelming righty who 4.47 SIERA and 18.5% strikeout rate last season. Montero struggled mightily vs. lefties (5.56 xFIP last season).
That's bad news against the likes of JJ Wetherholt, Nolan Gorman and Alec Burleson.
Cardinals vs Tigers Picks
Kyle Leahy came into the year as a popular sleeper in deeper fantasy leagues, so he has some intrigue. He has a curveball that induced a 35.1% whiff rate last season.
Action PRO projects him for 3.8 strikeouts tonight.
We saw some impressive outings from Leahy as a long reliever last year, including seven strikeouts across 3.2 innings against the Rockies at Coors Field.
I'm betting that he can get back on track at Comerica Park.
The other angle of this pick is me fading Keider Montero. The two best hitters on the Cardinals, Wetherholt and Burleson, each bat left-handed.
Montero was atrocious against lefties last year, so that may hurt him in this one.
I'll stick with the first five innings with this pick because I'm zeroing in on the pitching matchup. I don't want to rely on the Cardinals bullpen here.
Pick: Cardinals F5 ML (+104, FanDuel)
