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The Milwaukee Brewers host the St. Louis Cardinals on September 27, 2026. First pitch from American Family Field is scheduled for 3:10 p.m. EDT. The game will be broadcast on CARD.
The Brewers are favored by -250 on the moneyline and by -1.5 on the run line. The Cardinals are +205 on the moneyline and +1.5 on the run line. The total is set at 7 runs.
Find our MLB picks and Cardinals vs Brewers prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Brewers Prediction
- Cardinals vs Brewers Pick: Jacob Misiorowski Over 6.5 Strikeouts (+105)
Our Cardinals vs Brewers best bet is on Jacob Misiorowski to record over 6.5 strikeouts. Make sure to find the best odds by checking our live MLB odds page. Be sure to download the Action Network app for more picks and analysis.
Cardinals vs Brewers Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -120 | 7 100o / -120u | +205 |
| Brewers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +100 | 7 100o / -120u | -250 |
- Cardinals vs Brewers moneyline: Cardinals +205, Brewers -250
- Cardinals vs Brewers over/under: 7 (+100o / -120u)
- Cardinals vs Brewers spread: Brewers -1.5 (+100 ), Cardinals +1.5 (-120)
Cardinals vs Brewers Probable Pitchers
| Andre Pallante (RHP, STL) | Stat | Jacob Misiorowski (RHP, MIL) |
|---|---|---|
| 12-8 | W-L | 15-5 |
| 2.7 | fWAR (FanGraphs) | 6.4 |
| 3.61/4.04 | ERA / xERA | 1.86/2.06 |
| 3.71/3.99 | FIP / xFIP | 2.16/2.23 |
| 8.7% | K-BB% | 31.7% |
| 56.1% | GB% | 44.8% |
| .280 | BABIP | .240 |
| 97 | Stuff+ | 128 |
| 104 | Location+ | 101 |
Cardinals vs Brewers MLB Betting Preview
The St. Louis Cardinals travel to Milwaukee to take on the Brewers in the regular-season finale, looking to snap a three-game losing streak.
St. Louis comes in at 77-84 overall, including a 39-41 road mark, and will aim to leverage their strength when finding contact, as they hold a 53-33 record when accumulating at least eight hits.
Meanwhile, the Milwaukee Brewers enter as the top-performing club in Major League Baseball with an impressive 102-59 record, including a dominant 54-26 home tally. The Brewers have taken command of the season series, winning 10 of the previous 12 encounters between these two NL Central rivals.
On the mound, Andre Pallante gets the nod for the Redbirds, carrying a 12-8 record with a 3.61 ERA, 1.24 WHIP, and 106 strikeouts into the match.
Opposing him for Milwaukee is Jacob Misiorowski, who boasts a stellar 15-5 record alongside a pristine 1.86 ERA, 0.80 WHIP, and 247 strikeouts.
On the offensive side, Alec Burleson continues his pursuit to secure the MLB RBI title as the regular season reaches its conclusion, while Milwaukee awaits its upcoming postseason run.
Cardinals vs Brewers Pick, Betting Analysis
Jacob Misiorowski takes the mound for his 30th start of the campaign as he puts the finishing touches on a remarkable Cy Young resume.
Action PRO projects Misiorowski for 8.12 Ks in this matchup against St. Louis. Comparing this output to his current prop line of over/under 6.5 strikeouts yields a strong 21.9% edge against the betting market, making the Over an A-grade selection.
Back Misiorowski to close his stellar campaign in impressive form before the playoffs.
Pick: Jacob Misiorowski Over 6.5 Strikeouts (+105)
