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MLB Best Bets Today: Predictions & Picks for Reds vs. Blue Jays, Rockies vs. White Sox More on Saturday, September 26

MLB Best Bets Today: Predictions & Picks for Reds vs. Blue Jays, Rockies vs. White Sox More on Saturday, September 26 article feature image
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Credit:

IMAGN IMAGES via Reuters Connect. Pictured: Rhett Lowder (top left), Randal Grichuk (top right), Dustin May (bottom right), Walker Buehler (bottom left)

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As the regular season comes to a close, we have 15 games in today's slate and plenty of action to pick from.

We have picks for Reds vs. Blue Jays at 4:07 PM ET, Rockies vs. White Sox at 7:10 PM ET, Cardinals vs. Brewers at 7:10 PM ET and Diamondbacks vs. Padres at 8:40 PM ET.

Read below for our 4 MLB Best Bets for Saturday.


MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Cincinnati Reds LogoToronto Blue Jays Logo
4:07 PM
Colorado Rockies LogoChicago White Sox Logo
7:10 PM
St. Louis Cardinals LogoMilwaukee Brewers Logo
7:10 PM
Arizona Diamondbacks LogoSan Diego Padres Logo
8:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Derek Carty's Reds vs Blue Jays Prop Pick

Cincinnati Reds Logo
Saturday, September 26
4:07 PM ET
MLB.TV
Toronto Blue Jays Logo
Rhett Lowder Over 14.5 Outs (-122)
FanDuel Logo

By Derek Carty

There may be some value on Rhett Lowder's pitching outs prop. THE BAT X is projecting him to record 16.35 pitching outs, and oddsmakers are implying 13.98.

The model believes there is a 75% chance he records at least 15 outs by pitching, so there is value on the over at -122. This play is good down to at least -216.

Pick: Rhett Lowder Over 14.5 Outs (-122, FanDuel)



Derek Carty's Rockies vs White Sox Prop Pick

Colorado Rockies Logo
Saturday, September 26
7:10 PM ET
MLB.TV
Chicago White Sox Logo
Randal Grichuk u1.5 Hits, Runs & Rbis (+120)
bet365 Logo

By Derek Carty

There is a value opportunity on Randal Grichuk's hits, runs and RBIs prop. THE BAT X is projecting him to record 1.79 hits, runs and RBIs, while oddsmakers are implying 2.25.

The model believes there is a 55% chance he records fewer than 2 hits, runs and RBIs, so there is value on the under at +120. This play is good down to at least +100.

Pick: Randal Grichuk u1.5 Hits, Runs & Rbis (+120, bet365)



Action PRO's Cardinals vs Brewers Prop Pick

St. Louis Cardinals Logo
Saturday, September 26
7:10 PM ET
MLB.TV
Milwaukee Brewers Logo
Dustin May Over 2.5 Strikeouts (-164)
DraftKings  Logo

By PRO Prop Projections

Action PRO's Prop Projections has identified this pick for Saturday’s matchup between the Cardinals and Brewers as a value edge.

Setting May’s prop at just 2.5 strikes creates an exceptionally low hurdle for a starting pitcher who averages nearly a strikeout per inning. May possesses a legitimate high-end swing-and-miss arsenal, driven by a high-velocity four-seam fastball and a sharp sweeper.

His recent game logs consistently demonstrate this bat-missing ability, routinely clearing 3 strikeouts and regularly reaching 4, 5, or 6 Ks in his starts. Even in an outing with an abridged pitch count or early bullpen hook, clearing 3 punchouts requires minimal workload given his output.

Against a familiar opponent, May's proven strikeout production makes taking the over a strongly supported play.

Pick: Dustin May Over 2.5 Strikeouts (-164)



Bet Lab's Diamondbacks vs Padres Best Bet

Arizona Diamondbacks Logo
Saturday, September 26
8:40 PM ET
MLB.TV
San Diego Padres Logo
Under 7.5 (-110)
FanDuel Logo

By Bet Labs

Action Network's Bet Labs flagged this pick under the "Contrarian Unders for Winning Teams" system.

When two winning teams square off, public bettors naturally gravitate toward the high-octane offense, inflating market totals. The system exploits this exact public bias. With both Arizona and San Diego carrying winning records, public action heavily backs the Over, pushing the line to 7.5 despite optimal conditions for a low-scoring affair.

Pitching matchups like Walker Buehler taking the mound for San Diego demand disciplined game management, while both clubs rely on high-leverage bullpen usage and elite late-game defense characteristic of winning teams contending late in the season.

Furthermore, playing at pitcher-friendly Petco Park suppressed run production in prior divisional clashes. Backing Under 7.5 capitalizes on the market's overreaction to offensive upside while siding with superior late-inning execution.

Pick: Under 7.5 (-110)



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