The Philadelphia Phillies host the St. Louis Cardinals on August 22, 2026. First pitch from Citizens Bank Park is scheduled for 6:05 p.m. ET. The game will be broadcast on NBCS-PH.
The Phillies are favored by -135 on the moneyline and by -1.5 on the run line. The Cardinals are +110 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find our MLB picks and Cardinals vs Phillies prediction below, as well as probable pitchers, weather report, and more.
Cardinals vs Phillies Prediction
- Cardinals vs Phillies Pick: Over 9 (-110)
Our Cardinals vs Phillies best bet is Over 9 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Phillies Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -190 | 9 -110o / -110u | +110 |
| Phillies Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 9 -110o / -110u | -135 |
- Cardinals vs Phillies moneyline: Cardinals +110, Phillies -135
- Cardinals vs Phillies over/under: 9 (-110o / -110u)
- Cardinals vs Phillies spread: Cardinals +1.5 (-190), Phillies -1.5 (+155)
Cardinals vs Phillies Probable Pitchers
| Quinn Mathews (LHP, STL) | Stat | Andrew Painter (RHP, PHI) |
|---|---|---|
| 0-1 | W-L | 2-8 |
| 0.1 | fWAR (FanGraphs) | 0.1 |
| 3.00 / 3.09 | ERA / xERA | 6.43 / 5.06 |
| 4.31 / 4.88 | FIP / xFIP | 5.38 / 4.74 |
| 9.8 | K-BB% | 9.7 |
| 37.5 | GB% | 40.0 |
| .292 | BABIP | .316 |
| 96 | Stuff+ | 102 |
| 104 | Location+ | 101 |
Cardinals vs Phillies MLB Betting Preview
Sean Zerillo's projections show solid value on the total for this Cardinals vs. Phillies matchup.
If you want to dive deeper into this matchup, it'd be wise to check out BARTOLO, Zerillo's new PRO baseball tool that gives you access to all the input data he uses to project games every day.
Cardinals vs Phillies Pick, Betting Analysis
BARTOLO projects the Cardinals for 4.48 runs and the Phillies for 4.81 today, which would bring the total over the line.
These are two of the hottest lineups in the league right now, with Philly ranking third and St. Louis holding the sixth spot in wRC+ in the last seven days.
The Cards would send the inexperienced Quinn Mathews to the hill, while Andrew Painter will start for the home team.
Painter has been a disappointment all season, and he's coming off a bad outing against the Twins, giving up two homers, five runs, and six hits, while walking three batters and striking out only two.
Both bullpens are near the bottom of the league in ERA, with 4.30 for the Cardinals (ranked 22nd) and 4.31 for the Phillies (24th).
Pick: Over 9 (-110, BetMGM)
