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Blue Jays vs Yankees Prediction, Pick, MLB Odds for Saturday, August 22

Blue Jays vs Yankees Prediction, Pick, MLB Odds for Saturday, August 22 article feature image
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Photo Credit: Kevin Sousa-Imagn Images
Pictured: Dylan Cease adjusts his hat

The New York Yankees host the Toronto Blue Jays on August 22, 2026. First pitch from Yankee Stadium is scheduled for 1:35 p.m. EDT. The game will be broadcast on YES.

The Yankees are -106 on the moneyline. The Blue Jays are -102 on the moneyline. The total is set at 6.5 runs.

Find my MLB picks and Blue Jays vs Yankees prediction below, as well as probable pitchers, weather report, and more.


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Blue Jays vs Yankees Prediction

  • Blue Jays vs Yankees Pick: Blue Jays ML (+117 | Play to +110)

My Blue Jays vs Yankees best bet is on Toronto to win. Make sure to find the best odds by checking our live MLB odds page.


Blue Jays vs Yankees Odds

Blue Jays Logo
Saturday, Aug 22
1:35 p.m. ET
YES
Yankees Logo
Blue Jays Odds
SpreadTotalMoneyline
-1.5
+172
6.5
-124o / 102u
-102
Yankees Odds
SpreadTotalMoneyline
+1.5
-210
6.5
-124o / 102u
-106
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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  • Blue Jays vs Yankees moneyline: Blue Jays -102, Yankees -106
  • Blue Jays vs Yankees over/under: 6.5 (-124 / +102)
  • Blue Jays vs Yankees spread: Blue Jays -1.5 (+172), Yankees +1.5 (-210)

Blue Jays vs Yankees Probable Pitchers

Dylan CeaseStatRyan Weathers
7-5W-L5-7
4.8fWAR (FanGraphs)2.4
2.42 / 2.65ERA / xERA3.56 / 4.20
2.37 / 2.70FIP / xFIP3.66 / 3.26
25.7K-BB%18.5
43.8GB%48.8
.278BABIP.295
107Stuff+103
98Location+108

Blue Jays vs Yankees MLB Betting Preview

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Toronto Blue Jays Betting Preview

The Blue Jays hand the ball to right-hander Dylan Cease, who should serve as a good candidate to back. Firmly in the AL Cy Young race, Cease has been brilliant this season.

Through 23 starts, the right-hander is 7-5 with a 2.42 ERA and a 1.06 WHIP. His underlying metrics are equally dominant.

Entering this matchup, Cease ranks in the 95th percentile or higher in xERA, xBA, average exit velocity and strikeout rate. He has been pitching particularly well lately, allowing two or fewer earned runs in four of his past five starts.

Cease is 1-0 over that stretch with a 1.62 ERA and a 0.81 WHIP.

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New York Yankees Betting Preview

Cease’s success is likely to continue against the Yankees. In 126 combined plate appearances against the right-hander, the current Yankees roster owns a .193 batting average and a .263 weighted on-base average.

Meanwhile, left-hander Ryan Weathers takes the mound for New York. Now is the time to sell high on Weathers, who enters this game in dominant form.

That said, his underlying metrics remain poor, suggesting that he has benefited from some favorable results and is due for regression. Despite his recent string of quality starts, Weathers still ranks in the bottom half of the league in xERA, xBA, average exit velocity and barrel rate.

That expected regression could occur against Toronto. In 66 combined plate appearances against Weathers, the current Blue Jays roster owns a .306 batting average, a .548 slugging percentage and a .381 weighted on-base average.


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Blue Jays vs Yankees Pick, Betting Analysis

There are three primary reasons New York is favored in this game: home-field advantage, Weathers’ recent dominance and the Yankees’ hitting.

That said, this line appears to be an overadjustment to those three factors, especially when examining them more closely. First, Weathers has pitched extremely well recently but still trails Cease in virtually every major pitching metric.

Second, while the Yankees are the superior hitting team, they still rank in the bottom half of the league in runs scored per game, hits per game, batting average and on-base percentage.

Home-field advantage is a legitimate factor in New York’s favor, but it is not enough to offset the other advantages Toronto possesses.

Pick: Blue Jays ML (+100 or Better)


Blue Jays vs Yankees Weather


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