The Auburn Tigers take on the Purdue Boilermakers in Indianapolis, Indiana. Tip-off is set for 6:30 p.m. ET on Peacock.
Purdue is favored by -8.5 points on the spread with a moneyline of -425. The total is set at 154 points.
Here’s my Auburn vs. Purdue prediction and college basketball picks for December 20, 2025.
Auburn vs Purdue Prediction
My Pick: Purdue -9.5 or Better
My Auburn vs Purdue best bet is on the Boilermakers to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Auburn vs. Purdue Odds
| Auburn Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+8.5 -110 | 154 -110o / -110u | +325 |
| Purdue Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-8.5 -110 | 154 -110o / -110u | -425 |
- Auburn vs Purdue spread: Purdue -8.5
- Auburn vs Purdue over/under: 154 points
- Auburn vs Purdue moneyline: Auburn +325, Purdue -425
Auburn vs Purdue College Basketball Betting Preview
Auburn Basketball
Auburn's strength on defense has been generating steals, but even that advantage is voided with the lack of turnovers the Boilermakers create. This isn’t a team you speed up or rattle.
Auburn can definitely score, with a 122.6 offensive efficiency and frequent trips to the free-throw line (FTA/FGA 46.8, 21st nationally).
The problem is that Purdue’s defense is designed to stop what Auburn does best.
We also need to take a look under the hood, given that Auburn has struggled against higher-quality opponents. I have a feeling the Tigers are going to be outclassed here, and I don't think the market is accounting for that yet.
The Boilers rarely foul, so if Auburn can’t get to the line, they have to rely more on jump shots. That’s a problem for the Tigers, as I think they're going to be handcuffed offensively for most of the contest.
Auburn shoots 34.2% from 3, which is solid, but Purdue’s defense holds teams to just 30.8% from deep, ranking in the top 100 nationally.
Inside the arc, Auburn makes 56.7% of its shots, but Purdue’s defense is tough there too, with opponents shooting only 48.4% on 2s (also top-100).
Purdue Basketball
Let’s be real, calling this a “neutral site” is a stretch. Technically, the game is on a neutral court, but playing in Indianapolis creates a home-like atmosphere for Purdue.
It’s not Mackey Arena, but I think it makes a big difference here. That matters in this matchup because Purdue’s style is exactly the kind that gives Auburn problems.
When Purdue has the ball, its stats really stand out. The Boilers currently rank first in the country in adjusted offensive efficiency. Auburn’s defense isn’t bad, but it’s only average in areas Purdue takes advantage of.
Purdue’s effective field goal percentage is 58.1% (19th nationally), while Auburn’s defense allows 50.5%. That’s a big difference, especially since Purdue is balanced all over the floor, shooting 39.5% from 3 and 57.4% inside the arc, making it tough to defend.
Purdue is also strong on the offensive glass, grabbing 42.3% of its missed shots, which ranks fourth in college basketball.
Auburn, on the other hand, lets opponents rebound 31.8% of misses (217th).
Being weak on the boards against Purdue is risky, especially with its size and knack for second-chance 3s.
Auburn vs. Purdue Betting Analysis
Auburn’s numbers look good on its own, but Purdue’s defense might be too much to overcome. There’s also a big experience gap.
Purdue is one of the most experienced teams in the nation, which gives Steve Pearl’s Tigers an uphill battle on their youthfulness alone.
Everything points to Purdue having the advantage. The Boilermakers' efficient half-court offense, strong rebounding and disciplined defense are a better fit against Auburn’s fast-paced style.
With a crowd in Indianapolis likely favoring Purdue, this so-called "neutral game" really isn’t neutral.
My Pick: Purdue -9.5 or Better
