The USC Trojans take on the Oregon Ducks in Eugene, OE. Tip-off is set for 10 p.m. ET on Fox Sports 1.
USC is favored by -1.5 points on the spread with a moneyline of -130. The total is set at 154.5 points.
Here’s my USC vs. Oregon predictions and college basketball picks for December 2, 2025.
USC vs Oregon Prediction
My Pick: USC -1.5
My USC vs Oregon best bet is on the Trojans to cover the spread. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
USC vs. Oregon Odds
| USC Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -115 | 155.5 -110o / -110u | -130 |
| Oregon Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -105 | 155.5 -110o / -110u | +110 |
- USC vs Oregon spread: USC -1.5
- USC vs Oregon over/under: 154.5 points
- USC vs Oregon moneyline: USC -130, Oregon +110
USC vs Oregon College Basketball Betting Preview
Tonight's Big Ten showdown at Matthew Knight Arena tips off with the No. 24 USC Trojans (7-0) dueling with the Oregon Ducks (4-3) in a conference opener that's already drawing heavy public steam toward the home underdog.
USC enters off a trophy-clinching 88-75 Maui Invitational championship win over Arizona State. The Trojans lean on Chad Baker-Mazara (20.3 PPG, 5.4 RPG), who scored 23 points in that final, and Rodney Rice's perimeter fire (20.3 PPG on 38.5% from deep).
The Trojans' half-court execution shines in these spots, with a +6.2 rebounding margin that could neutralize Oregon's paint attack.
The Ducks, meanwhile, limp in after going 0-3 at the Players Era Festival, capped by a 76-66 stumble to Creighton, where their offense stalled at 1-of-15 from deep. They also managed just 11 assists in that game.
Jackson Shelstad (15.7 PPG) carries the load, but Oregon's home inconsistencies persist (2-1 ATS at Matthew Knight).
The Ducks are also coughing up 13.4 turnovers per contest against perimeter pressure like USC's.
This matchup screams inflated line driven by public perception. Oregon's recognizable brand and home-court advantage have casual bettors piling on the +1.5, pumping betting volume sky-high in this prime-time slot.
In the Big Ten's high-visibility games, sportsbooks shade toward home favorites on reputation, but history shows the market imbalance fades the public. Teams like USC in these undervalued road roles cover at a 62% clip over the last three seasons when lines inflate under three points on elevated action.
My Pick: USC -1.5
