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College Football Odds, Picks Week 4: Clemson vs. Wake Forest, Florida vs. Tennessee Lead Sharpest Early Bets

College Football Odds, Picks Week 4: Clemson vs. Wake Forest, Florida vs. Tennessee Lead Sharpest Early Bets article feature image
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Photo by Kevin Langley/Icon Sportswire via Getty Images. Pictured: Tennessee defensive back Kamal Hadden

You know that they say about sports betting (probably): “There’s no rest for the weary, especially following NFL Monday Night Football doubleheaders.”

An epic weekend of football betting was capped off with two Monday Night Football matchups, capturing the attention of most bettors even more than normal Monday nights.

However, while many of you were singularly-focused on Titans vs. Bills and Vikings vs. Eagles on Monday, college football Week 4 odds were open for business and wiseguys took full advantage.

So in case you haven’t had the time to give college football odds for Week 4 your attention, I’ve leveraged Action Labs’ Bet Signals data to identify four bets that sharps are already making, including:

  • No. 7 Clemson vs. No. 21 Wake Forest
  • No. 20 Florida vs. No. 11 Tennessee
  • Hawaii vs. New Mexico State
  • Western Michigan vs. San Jose State

College Football Picks for Week 4

*Odds as of Tuesday morning 

Clemson vs. Wake Forest Pick

Noon ET | ABC

This has quietly become a huge matchup in the ACC, and Clemson vs. Wake Forest odds movement has also been very interesting early in Week 4.

The Tigers opened as 8.5-point road favorites over the Demon Deacons, yet pro bettors have already taken a market-moving position on Wake Forest.

Smart money has pushed this spread down to between +7 and +7.5, depending on the sportsbook, confirming that oddsmakers are heavy with Wake Forest money to this point.

Because seven is so important in football betting, it’s crucial to shop for the best line if you plan on pouncing on the Demon Deacons as well.

For example, BetMGM and FanDuel are offering Wake Forest at +7.5 (-115).

Don’t settle for a bad number when there’s free line value ripe for the picking.

Pick: Wake Forest +7.5 (-115)

Florida vs. Tennessee Pick

3:30 p.m. ET | CBS

A huge, early-season matchup between two ranked teams with extremely noteworthy odds movement, you say?

Let me introduce you to Florida vs. Tennessee, which may be even more intriguing from a betting perspective than Clemson vs. Wake Forest above.

The Vols hit the market at -7.5 against the Gators earlier this week and sharps fell over themselves getting down on Tennessee in this key SEC East matchup.