The Duke Blue Devils take on the Clemson Tigers in Clemson, South Carolina. Kickoff is set for 12:00 p.m. EDT on ACC Network.
Clemson is favored by 2.5 points on the spread with a moneyline of -150. The total is set at 54.5 points.
Here’s my Duke vs. Clemson predictions and college football picks for Saturday, November 1, 2025.
Duke vs Clemson Prediction
- Duke vs. Clemson Pick: Duke +2.5 (-110, bet365)
My Clemson vs. Duke best bet is on the Blue Devils. Find the best line available on our live NCAAF odds page.
Duke vs Clemson Odds
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -105 | 54.5 -110o / -110u | +125 |
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -115 | 54.5 -110o / -110u | -150 |
- Duke vs Clemson point spread: Clemson -2.5 (-115), Duke +2.5 (-105)
- Duke vs Clemson over/under: 54.5 (-110o / -110u)
- Duke vs Clemson moneyline: Duke +120, Clemson -150
Duke vs Clemson Pick
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
Mature Market Moves is a college football system that capitalizes on the influence of sharp money when it differs meaningfully from public betting patterns.
In the regular season, when the spread falls between 1 and 6 points, these games are often competitive and decided by narrow margins, making line efficiency critical.
By isolating matchups where the percentage of money wagered is significantly higher than the percentage of tickets, the system highlights situations where larger, more informed bets are backing one side while casual bettors are spread differently.
Limiting the sample to games five and later ensures teams have established trends and reliable data to target sharper action.
This combination of tight spreads, mature markets, and a clear split between sharp money and public opinion creates an edge in which following the money side outperforms expectations.
Per the Action App, Duke is currently generating 54% of the betting tickets but over 90% of the betting handle.
I'm willing to back the Blue Devils with those splits.
I haven't believed in the Tigers since the preseason. They've done nothing but unimpress, including last week's 11-point home loss to SMU. They can't run the ball, and their defense is simply mediocre.
Duke is only 4-3, but the Devils have won three of four ACC games, and they rank 20th nationally in Net Success Rate (+7.9%). I think they're still a tad undervalued.
I wouldn't be surprised if Darian Mensah and Co. pulled off the outright upset — the Tulane transfer quarterback has been near perfect in league play, completing 73% of his passes for 1,175 yards at nine YPA with nine touchdowns to no interceptions (and seven Big Time Throws to one Turnover Worthy Play).
Pick: Duke +2.5 (-110, bet365)
