The East Carolina Pirates take on the UTSA Roadrunners in San Antonio, Texas. Kickoff is set for 3:30 p.m. EST on ESPN+.
East Carolina is favored by 2.5 points on the spread with a moneyline of -135. The total is set at 62.5 points.
Here’s my East Carolina vs. UTSA prediction and college football picks for Saturday, November 22, 2025.
East Carolina vs UTSA Prediction
- East Carolina vs. UTSA Pick: UTSA +3 or Better
My UTSA vs. East Carolina best bet is on the Roadrunners to cover. Find the best line available on our live NCAAF odds page.
East Carolina vs UTSA Odds
| E. Carolina Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 62.5 -110o / -110u | -135 |
| UTSA Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 62.5 -110o / -110u | +115 |
- East Carolina vs UTSA point spread: East Carolina -2.5 (-110), UTSA +2.5 (-110)
- East Carolina vs UTSA over/under: 62.5 (-110o / -110u)
- East Carolina vs UTSA moneyline: East Carolina -135, UTSA +115
East Carolina vs UTSA Preview
Here's a roadmap for betting on UTSA under head coach Jeff Traylor.
Are the Roadrunners at home? If yes, then they are worth a look.
If not, it's probably a pass.
The Roadrunners have been absolutely dominant at home under Traylor, and I believe that continues on Saturday afternoon in San Antonio.
Keep in mind they have played five of their past seven games on the road, while the opposite has been true for the Pirates, who have played five of their past seven in Greenville.
I believe that's creating a bit of value on the home dog in a game I make close to a coin flip.
I think we have reached the peak of the ECU market, which remains in contention for an American title. However, this is still a team with two road wins on the year:
- At Temple against an Owls defense that had all backups in the secondary.
- At Coastal Carolina, early in the season, before the Chants figured some things out and changed quarterbacks.
That's it.
Meanwhile, UTSA has only played two home league games so far. It won both (including one against Tulane) by a combined score of 109-39.
This is just a different team in the Alamodome.
I also believe Owen McCown wasn't fully healthy earlier in the season, but he finally looks like himself again.
ECU has a very stout run defense, but can be had through the air, which is precisely how McCown and company will look to attack the Pirates from the very opening drive.
In what should be a back-and-forth affair, I'll take the points with the very reliable home team that's looking to play spoiler and clinch a postseason berth themselves.
Pick: UTSA +3 or Better
